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MedKoo Cat#: 146046 | Name: Norswertianolin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norswertianolin is a naturally occurring flavonoid compound found in certain plants, particularly in species of Swertia. It is known for its potential therapeutic properties, including anti-inflammatory, antioxidant, and antimicrobial effects. Norswertianolin works by modulating key signaling pathways, such as the NF-κB pathway, to reduce inflammation and oxidative stress, which may help in the treatment of chronic inflammatory diseases. Its ability to inhibit the growth of various pathogens also suggests it could be useful in the development of natural antimicrobial treatments.

Chemical Structure

Norswertianolin
Norswertianolin
CAS#54954-12-0

Theoretical Analysis

MedKoo Cat#: 146046

Name: Norswertianolin

CAS#: 54954-12-0

Chemical Formula: C19H18O11

Exact Mass: 422.0800

Molecular Weight: 422.34

Elemental Analysis: C, 54.03; H, 4.30; O, 41.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Norswertianolin;
IUPAC/Chemical Name
1,3,5-trihydroxy-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9H-xanthen-9-one
InChi Key
MYWLBRTZOYHDOU-FJMCMGCSSA-N
InChi Code
1S/C19H18O11/c20-5-11-14(24)16(26)17(27)19(30-11)29-9-2-1-7(22)18-13(9)15(25)12-8(23)3-6(21)4-10(12)28-18/h1-4,11,14,16-17,19-24,26-27H,5H2/t11-,14-,16+,17-,19-/m1/s1
SMILES Code
OC[C@H]1O[C@@H](OC2=C3C(=O)C4=C(O)C=C(O)C=C4OC3=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 422.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Niu Y, Du C, Cui C, Zhang H, Deng Y, Cai J, Chen Z, Geng B. Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension. Front Pharmacol. 2021 Jul 14;12:677212. doi: 10.3389/fphar.2021.677212. PMID: 34335249; PMCID: PMC8317460. 2: Urbain A, Marston A, Grilo LS, Bravo J, Purev O, Purevsuren B, Batsuren D, Reist M, Carrupt PA, Hostettmann K. Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. J Nat Prod. 2008 May;71(5):895-7. doi: 10.1021/np070690l. Epub 2008 Mar 13. PMID: 18336006. 3: Lin Q, Cui C, Zhao Y, Geng Y, Gao H, Shao X, Cheng L, Li H, Geng B. Cystathionine γ-Lyase Attenuates Vascular Smooth Muscle Cell Senescence via Foxm1-Gas1 Pathway to Mediate Arterial Stiffness. Antioxid Redox Signal. 2024 Sep 30. doi: 10.1089/ars.2024.0602. Epub ahead of print. PMID: 39226170. 4: Wang Z, Wu Q, Yu Y, Yang C, Jiang H, Wang Q, Yang B, Kuang H. Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC-ESI-MS/MS. J Ethnopharmacol. 2015 Nov 4;174:261-9. doi: 10.1016/j.jep.2015.08.023. Epub 2015 Aug 20. PMID: 26297839. 5: Ren K, Su H, Lv LJ, Yi LT, Gong X, Dang LS, Zhang RF, Li MH. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide- Induced Injury in H9c2 Cells. Biomed Res Int. 2019 Jan 20;2019:2692970. doi: 10.1155/2019/2692970. PMID: 30800665; PMCID: PMC6360564. 6: Chung MI, Gan KH, Lin CN, Chen IJ. Studies on the constituents of Formosan gentianaceous plants. Part VII. Constituents of Swertia randaiensis Hayata and pharmacological activity of norswertianolin. Gaoxiong Yi Xue Ke Xue Za Zhi. 1986 Feb;2(2):131-5. PMID: 3482877. 7: Urbain A, Marston A, Queiroz EF, Ndjoko K, Hostettmann K. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004 Oct;70(10):1011-4. doi: 10.1055/s-2004-832632. PMID: 15490334. 8: Matsushima T, Araki A, Yagame O, Muramatsu M, Koyama K, Ohsawa K, Natori S, Tomimori H. Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637. Mutat Res. 1985 Jun-Jul;150(1-2):141-6. doi: 10.1016/0027-5107(85)90111-3. PMID: 3889613. 9: Wani BA, Ramamoorthy D, Rather MA, Arumugam N, Qazi AK, Majeed R, Hamid A, Ganie SA, Ganai BA, Anand R, Gupta AP. Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents. Phytomedicine. 2013 Jun 15;20(8-9):723-33. doi: 10.1016/j.phymed.2013.01.011. Epub 2013 Mar 1. PMID: 23453831. 10: Olennikov DN, Chirikova NK, Vennos C. Chemical Composition, Antioxidant and Anticholinesterase Activities of Gentianella azurea from Russian Federation. Nat Prod Commun. 2017 Jan;12(1):55-56. PMID: 30549824. 11: Chen Y, Wang GK, Wu C, Qin MJ. [Chemical constituents of Gentiana rhodantha]. Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(3):362-5. Chinese. PMID: 23668010. 12: Zeng GY, Tan GS, Xu KP, Xu XP, Li FS, Tan JB, Hu GY. [Water-soluble chemical constituents of Swertia davidi Franch]. Yao Xue Xue Bao. 2004 May;39(5):351-3. Chinese. PMID: 15338877. 13: Tovilovic-Kovacevic G, Krstic-Milosevic D, Vinterhalter B, Toljic M, Perovic V, Trajkovic V, Harhaji-Trajkovic L, Zogovic N. Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line. Phytomedicine. 2018 Aug 1;47:151-160. doi: 10.1016/j.phymed.2018.03.052. Epub 2018 Mar 19. PMID: 30166100. 14: Wang H, Geng C, Zhang X, Ma Y, Jiang Z, Chen J. [Chemical constituents of Swertia macrosperma]. Zhongguo Zhong Yao Za Zhi. 2010 Dec;35(23):3161-4. Chinese. PMID: 21355239. 15: Xu K, Shen J, Li F, Liu J, Liu G, Tan J, Tan G. [Determination of six active components in three species of genus Swertia by HPLC multiwavelength with detection]. Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1384-9. Chinese. PMID: 19771868.