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MedKoo Cat#: 128595 | Name: JSF-4898

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JSF-4898 is a Mycobacterium tuberculosis inhibitor. JSF-4898 demonstrated significantly improved biological profiles, notably offering submicromolar MIC values versus M. tuberculosis and promising values characterizing the mouse liver microsome stability, aqueous solubility, and mouse pharmacokinetic profile. JSF-4898 enhanced the efficacy of rifampicin in a subacute model of M. tuberculosis infection in mice.

Chemical Structure

JSF-4898
JSF-4898
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128595

Name: JSF-4898

CAS#: N/A

Chemical Formula: C21H21ClFN3O3

Exact Mass: 417.1255

Molecular Weight: 417.87

Elemental Analysis: C, 60.36; H, 5.07; Cl, 8.48; F, 4.55; N, 10.06; O, 11.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JSF-4898; JSF4898; JSF 4898
IUPAC/Chemical Name
2-chloro-4-fluoro-N-(6-methoxy-5-(4-(methylcarbamoyl)cyclohex-1-en-1-yl)pyridin-3-yl)benzamide
InChi Key
WSOZLMZACCYDAW-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21ClFN3O3/c1-24-19(27)13-5-3-12(4-6-13)17-10-15(11-25-21(17)29-2)26-20(28)16-8-7-14(23)9-18(16)22/h3,7-11,13H,4-6H2,1-2H3,(H,24,27)(H,26,28)
SMILES Code
FC1=CC=C(C(NC2=CC(C3=CCC(C(NC)=O)CC3)=C(OC)N=C2)=O)C(Cl)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 417.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Sharma P, Jiang Q, Li SG, Ocke E, Tsotetsi K, Sukheja P, Singh P, Suryavanshi S, Morrison E, Thadkapally S, Russo R, Penalva-Lopez S, Cangialosi J, Sharma V, Johnson K, Sarathy JP, Nelson AM, Park S, Zimmerman MD, Alland D, Kumar P, Freundlich JS. Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis. J Med Chem. 2025 Mar 4. doi: 10.1021/acs.jmedchem.4c03156. Epub ahead of print. PMID: 40035499.

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