MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 146027 | Name: Rhodionin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rhodionin is a naturally occurring compound found in certain plants, known for its potential antimicrobial and antioxidant properties. It has been studied for its applications in treating bacterial infections and reducing oxidative stress in the body. Rhodionin’s mechanism of action involves disrupting bacterial cell membrane integrity, leading to cell death, and scavenging free radicals to protect cells from oxidative damage. This dual action makes rhodionin a promising candidate for use in antimicrobial therapies and as a natural antioxidant agent in various health applications.

Chemical Structure

Rhodionin
Rhodionin
CAS#85571-15-9

Theoretical Analysis

MedKoo Cat#: 146027

Name: Rhodionin

CAS#: 85571-15-9

Chemical Formula: C21H20O11

Exact Mass: 448.1000

Molecular Weight: 448.38

Elemental Analysis: C, 56.25; H, 4.50; O, 39.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
RHODIONIN;
IUPAC/Chemical Name
3,5,8-trihydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChi Key
CIAXXTSXVCLEJK-JOEVVYSCSA-N
InChi Code
1S/C21H20O11/c1-7-13(24)16(27)18(29)21(30-7)31-11-6-10(23)12-15(26)17(28)19(32-20(12)14(11)25)8-2-4-9(22)5-3-8/h2-7,13,16,18,21-25,27-29H,1H3/t7-,13-,16+,18+,21-/m0/s1
SMILES Code
C[C@@H]1O[C@@H](OC2=CC(O)=C3C(=O)C(O)=C(OC3=C2O)C4=CC=C(O)C=C4)[C@H](O)[C@H](O)[C@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang X, Luan Y, Hou J, Jiang T, Zhao Y, Song W, Wang L, Kong X, Guan J, Song D, Wang B, Li M. The protection effect of rhodionin against methicillin- resistant Staphylococcus aureus-induced pneumonia through sortase A inhibition. World J Microbiol Biotechnol. 2022 Nov 21;39(1):18. doi: 10.1007/s11274-022-03457-4. PMID: 36409383. 2: Li T, Zhang H. Identification and comparative determination of rhodionin in traditional tibetan medicinal plants of fourteen Rhodiola species by high- performance liquid chromatography-photodiode array detection and electrospray ionization-mass spectrometry. Chem Pharm Bull (Tokyo). 2008 Jun;56(6):807-14. doi: 10.1248/cpb.56.807. PMID: 18520085. 3: Xu W, Zhang T, Wang Z, Liu T, Liu Y, Cao Z, Sui Z. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea. Pharmazie. 2013 Dec;68(12):974-6. PMID: 24400445. 4: Erst AA, Petruk AA, Zibareva LN, Erst AS. Morphological, Histochemical and Biochemical Features of Cultivated Rhodiola rosea (Altai Mountains Ecotype). Contemp Probl Ecol. 2021;14(6):701-710. doi: 10.1134/S1995425521060135. Epub 2021 Dec 20. PMID: 34956551; PMCID: PMC8685791. 5: Li FJ, Liu Y, Yuan Y, Yang B, Liu ZM, Huang LQ. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532. doi: 10.1016/j.ijbiomac.2017.06.066. Epub 2017 Jun 16. PMID: 28625836. 6: Wang L, Wu L, Li J, Cailang B, Zhao X, Yue H. Rhodiosin from Rhodiola crenulata effectively alleviate postprandial hyperglycemia by inhibiting both the activity and production of α‑glucosidase. Phytomedicine. 2024 Sep;132:155836. doi: 10.1016/j.phymed.2024.155836. Epub 2024 Jun 22. PMID: 38941814. 7: Slimestad R, Johny A, Thomsen MG, Karlsen CR, Rosnes JT. Chemical Profiling and Biological Activity of Extracts from Nine Norwegian Medicinal and Aromatic Plants. Molecules. 2022 Oct 28;27(21):7335. doi: 10.3390/molecules27217335. PMID: 36364156; PMCID: PMC9656764. 8: Choe KI, Kwon JH, Park KH, Oh MH, Kim MH, Kim HH, Cho SH, Chung EK, Ha SY, Lee MW. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR. Molecules. 2012 Sep 27;17(10):11484-94. doi: 10.3390/molecules171011484. PMID: 23018923; PMCID: PMC6268498. 9: Kobayashi K, Yamada K, Murata T, Hasegawa T, Takano F, Koga K, Fushiya S, Batkhuu J, Yoshizaki F. Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal. Planta Med. 2008 Nov;74(14):1716-9. doi: 10.1055/s-0028-1088318. Epub 2008 Nov 3. PMID: 18982538. 10: Liu GD, Zhao YW, Li YJ, Wang XJ, Si HH, Huang WZ, Wang ZZ, Ma SP, Xiao W. Qualitative and quantitative analysis of major constituents from Dazhu Hongjingtian capsule by UPLC/Q-TOF-MS/MS combined with UPLC/QQQ-MS/MS. Biomed Chromatogr. 2017 Jun;31(6). doi: 10.1002/bmc.3887. Epub 2017 Jan 16. PMID: 27862112. 11: Ionov NS, Baryshnikova MA, Bocharov EV, Pogodin PV, Lagunin AA, Filimonov DA, Karpova RV, Kosorukov VS, Stilidi IS, Matveev VB, Bocharova OA, Poroikov VV. Vozmozhnosti otsenok in silico dlia razrabotki farmkompozitsii fitoladaptogen, tsitotoksichnoĭ dlia kletok raka mochevogo puzyria [Possibilities of in silico estimations for the development of pharmaceutical composition phytoladaptogene cytotoxic for bladder cancer cells]. Biomed Khim. 2021 May;67(3):278-288. Russian. doi: 10.18097/PBMC20216703278. PMID: 34142535. 12: Ma S, Hu L, Ma C, Lv W, Wang H. Application and recovery of ionic liquids in the preparative separation of four flavonoids from Rhodiola rosea by on-line three-dimensional liquid chromatography. J Sep Sci. 2014 Sep;37(17):2314-21. doi: 10.1002/jssc.201400305. Epub 2014 Jul 10. PMID: 24916654. 13: Fan W, Tezuka Y, Ni KM, Kadota S. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401. doi: 10.1248/cpb.49.396. PMID: 11310664. 14: Liang ZL, Zhang XY, Wang F, Zhang K, Liu HF, Liu HL. Understanding molecular mechanisms of Rhodiola rosea for the treatment of acute mountain sickness through computational approaches (a STROBE-compliant article). Medicine (Baltimore). 2018 Sep;97(39):e11886. doi: 10.1097/MD.0000000000011886. PMID: 30278484; PMCID: PMC6181534. 15: Wang JX, Luo DQ, Zhao XY. [Studies on the chemical constituents of Rhodiola dumulosa (II)]. Zhong Yao Cai. 2006 Apr;29(4):335-6. Chinese. PMID: 16913487.