ZJY-54 is a LSD1/EGFRL858R/T790M Dual Inhibitor for Treating EGFR Mutant NSCLC Cancers. ZJY-54 effectively inhibited growth in both parent- and TKI-resistant NSCLC cells. In H1975 cells, ZJY-54 induced accumulation of H3K4me2 and H3K9me2, as well as inhibited phosphorylation of EGFR signaling. ZJY-54 showed favorable PK profiles and effectively inhibited tumor growth in the H1975 xenograft model.
MedKoo Cat#: 128580
Name: ZJY-54
CAS#: N/A
Chemical Formula: C29H30D3N7O2
Exact Mass: 514.2884
Molecular Weight: 514.65
Elemental Analysis: C, 67.68; H, 7.05; N, 19.05; O, 6.22
The following data is based on the product molecular weight 514.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
