MedKoo Cat#: 146008 | Name: Coccinine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Coccinine is a natural alkaloid compound found in the plant Coccinia grandis, known for its potential pharmacological properties. It exhibits anti-inflammatory, antioxidant, and antidiabetic effects, and is believed to act by modulating oxidative stress and inflammatory pathways in the body. The compound works by inhibiting key enzymes involved in inflammation and reducing the damage caused by free radicals. Coccinine is being studied for its applications in managing conditions like diabetes, cardiovascular diseases, and chronic inflammation.

Chemical Structure

Coccinine
Coccinine
CAS#485-57-4

Theoretical Analysis

MedKoo Cat#: 146008

Name: Coccinine

CAS#: 485-57-4

Chemical Formula: C17H19NO4

Exact Mass: 301.1300

Molecular Weight: 301.34

Elemental Analysis: C, 67.76; H, 6.36; N, 4.65; O, 21.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Coccinine;
IUPAC/Chemical Name
(6R,6aS,8S,9R,11S)-9-methoxy-5,6a,7,8,9,11-hexahydro-6,11-methano[1,3]dioxolo[4',5':4,5]benzo[1,2-e]benzo[b]azepin-8-ol
InChi Key
MKYLOMHWHWEFCT-ZQDZILKHSA-N
InChi Code
1S/C17H19NO4/c1-20-15-4-11-12-7-18(13(11)5-14(15)19)6-9-2-16-17(3-10(9)12)22-8-21-16/h2-4,12-15,19H,5-8H2,1H3/t12-,13-,14-,15+/m0/s1
SMILES Code
[H][C@]12C[C@H](O)[C@H](OC)C=C1[C@H]3C[N@@]2CC4=CC5=C(OCO5)C=C34
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 301.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pearson WH, Lian BW. Application of the 2-Azaallyl Anion Cycloaddition Method to an Enantioselective Total Synthesis of (+)-Coccinine. Angew Chem Int Ed Engl. 1998 Jul 3;37(12):1724-1726. doi: 10.1002/(SICI)1521-3773(19980703)37:12<1724::AID-ANIE1724>3.0.CO;2-8. PMID: 29711499. 2: Jani NA, Sirat HM, Ahmad F, Aminudin NI. New sesquiterpene dilactone and β-carboline alkaloid and the α-glucosidase inhibitory activity of selected phytochemicals from Neolitsea cassia (L.) Kosterm. Nat Prod Res. 2022 Aug;36(16):4061-4069. doi: 10.1080/14786419.2021.1961134. Epub 2021 Aug 3. PMID: 34343060.