Chloroflumazenil is a derivative of flumazenil, a well-known benzodiazepine receptor antagonist. It works by binding to the GABA-A receptor, specifically at the benzodiazepine site, thereby reversing the sedative effects of benzodiazepine drugs. Chloroflumazenil is being investigated for its potential to treat benzodiazepine overdose or toxicity by acting as a competitive antagonist at the receptor. Its applications are primarily in emergency medicine, where it may help in cases of overdose, though its precise role and efficacy are still being studied.
MedKoo Cat#: 146006
Name: Chloroflumazenil
CAS#: 78756-33-9
Chemical Formula: C15H14ClN3O3
Exact Mass: 319.0700
Molecular Weight: 319.75
Elemental Analysis: C, 56.35; H, 4.41; Cl, 11.09; N, 13.14; O, 15.01
The following data is based on the product molecular weight 319.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
