HMR-279 is a selective antagonist of the angiotensin II type 1 (AT1) receptor, which plays a key role in regulating blood pressure and fluid balance. By blocking the binding of angiotensin II to the AT1 receptor, HMR-279 helps to lower blood pressure, reduce vasoconstriction, and alleviate fluid retention, making it a potential treatment for hypertension and heart failure. The compound's mechanism involves the inhibition of the harmful effects associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). HMR-279 is being studied for its applications in managing cardiovascular conditions, particularly in patients with hypertension and related complications.
MedKoo Cat#: 146000
Name: HMR-279
CAS#: 185915-32-6
Chemical Formula: C14H11N3O2
Exact Mass: 253.0900
Molecular Weight: 253.26
Elemental Analysis: C, 66.40; H, 4.38; N, 16.59; O, 12.63
The following data is based on the product molecular weight 253.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
