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MedKoo Cat#: 145986 | Name: Ramulosin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ramulosin is a natural flavonoid compound found in plants like Sophora japonica and Gleditsia sinensis. It exhibits various bioactive properties, including antioxidant, anti-inflammatory, and antimicrobial effects. The mechanism of ramulosin involves the modulation of cellular pathways such as reducing oxidative stress and inflammation, which can contribute to protecting cells from damage and supporting overall health. Its potential applications include the development of therapeutic agents for conditions like cardiovascular diseases, cancer, and inflammatory disorders.

Chemical Structure

Ramulosin
Ramulosin
CAS#29914-01-0

Theoretical Analysis

MedKoo Cat#: 145986

Name: Ramulosin

CAS#: 29914-01-0

Chemical Formula: C10H14O3

Exact Mass: 182.0900

Molecular Weight: 182.22

Elemental Analysis: C, 65.92; H, 7.74; O, 26.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ramulosin; Ramulosine; NSC-112906; NSC112906; NSC 112906;
IUPAC/Chemical Name
(3R,4aS)-8-hydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-1H-isochromen-1-one
InChi Key
XQHOYOKXFNTNQZ-RQJHMYQMSA-N
InChi Code
1S/C10H14O3/c1-6-5-7-3-2-4-8(11)9(7)10(12)13-6/h6-7,11H,2-5H2,1H3/t6-,7+/m1/s1
SMILES Code
[H][C@@]12CCCC(O)=C1C(=O)O[C@H](C)C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: HENDERSHOT WF, HESSELTINE CW, PRIDHAM TG, BENEDICT RG, JACKSON RW. Ramulosin: inhibitory effect against plant seeds and various fungi. Arch Biochem Biophys. 1962 Jan;96:166-70. doi: 10.1016/0003-9861(62)90466-6. PMID: 13906388. 2: Chen S, Zhang Z, Li L, Liu X, Ren F. Two new ramulosin derivatives from the entomogenous fungus Truncatella angustata. Nat Prod Commun. 2015 Feb;10(2):341-4. PMID: 25920279. 3: Stodola FH, Cabot C, Benjamin CR. Structure of ramulosin, a metabolic product of the fungus Pestalotia ramulosa. Biochem J. 1964 Oct;93(1):92-7. doi: 10.1042/bj0930092. PMID: 5838107; PMCID: PMC1206186. 4: Shin HJ, Anh CV, Cho DY, Choi DK, Kang JS, Trinh PTH, Choi BK, Lee HS. New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti- Neuroinflammatory and Cytotoxic Activities. Molecules. 2021 Feb 5;26(4):836. doi: 10.3390/molecules26040836. PMID: 33562648; PMCID: PMC7915668. 5: El-Beih AA, Kato H, Ohta T, Tsukamoto S. (3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: a new ramulosin derivative from a marine-derived sterile mycelium. Chem Pharm Bull (Tokyo). 2007 Jun;55(6):953-4. doi: 10.1248/cpb.55.953. Erratum in: Chem Pharm Bull (Tokyo). 2007 Dec;55(12):1776. PMID: 17541203. 6: Vayer M, Fang W, Guillot R, Bezzenine-Lafollée S, Bour C, Gandon V. Acid- catalysed intramolecular addition of β-ketoesters to 1,3-dienes. Org Biomol Chem. 2017 Jan 18;15(3):584-588. doi: 10.1039/c6ob02122k. PMID: 27775130. 7: Stierle DB, Stierle AA, Kunz A. Dihydroramulosin from Botrytis sp. J Nat Prod. 1998 Oct;61(10):1277-8. doi: 10.1021/np9703407. PMID: 9784167. 8: Intaraudom C, Bunbamrung N, Dramae A, Boonyuen N, Kongsaeree P, Srichomthong K, Supothina S, Pittayakhajonwut P. Terphenyl derivatives and drimane - Phathalide/isoindolinones from Hypoxylon fendleri BCC32408. Phytochemistry. 2017 Jul;139:8-17. doi: 10.1016/j.phytochem.2017.03.008. Epub 2017 Apr 3. PMID: 28384525. 9: Zhou YH, Zhang M, Zhu RX, Zhang JZ, Xie F, Li XB, Chang WQ, Wang XN, Zhao ZT, Lou HX. Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity. J Nat Prod. 2016 Sep 23;79(9):2149-57. doi: 10.1021/acs.jnatprod.5b00998. Epub 2016 Aug 24. PMID: 27556953. 10: Surup F, Kuhnert E, Liscinskij E, Stadler M. Silphiperfolene-Type Terpenoids and Other Metabolites from Cultures of the Tropical Ascomycete Hypoxylon rickii (Xylariaceae). Nat Prod Bioprospect. 2015 Jun;5(3):167-73. doi: 10.1007/s13659-015-0065-3. Epub 2015 Jun 16. PMID: 26077652; PMCID: PMC4488154. 11: Wang J, Wang G, Zhang Y, Zheng B, Zhang C, Wang L. Isolation and identification of an endophytic fungus Pezicula sp. in Forsythia viridissima and its secondary metabolites. World J Microbiol Biotechnol. 2014 Oct;30(10):2639-44. doi: 10.1007/s11274-014-1686-0. Epub 2014 Jun 14. PMID: 24928260. 12: Maul C, Sattler I, Zerlin M, Hinze C, Koch C, Maier A, Grabley S, Thiericke R. Biomolecular-chemical screening: a novel screening approach for the discovery of biologically active secondary metabolites. III. New DNA-binding metabolites. J Antibiot (Tokyo). 1999 Dec;52(12):1124-34. doi: 10.7164/antibiotics.52.1124. PMID: 10695676.

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