Synonym
Iodoquine; WR-7910; WR 7910; WR7910;
IUPAC/Chemical Name
N1,N1-diethyl-N4-(7-iodoquinolin-4-yl)pentane-1,4-diamine
InChi Key
QCZZTGLRWDAZMG-UHFFFAOYSA-N
InChi Code
1S/C18H26IN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
SMILES Code
CCN(CC)CCCC(C)NC1=CC=NC2=C1C=CC(I)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
247.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shan L. N1,N1-diethyl-N4-(7-[125I ]iodoquinolin-4-yl)pentane-1,4-diamine. 2012 Mar 19 [updated 2012 May 2]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 22574337.
2: Chin BB, Hjelemand A, Rich J, Song H, Lascola C, Storms R, McLendon R, Reiman R, Greer KL, Metzler SD, McDougald D, Dai D, Vaidyanathan G. Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression. Curr Radiopharm. 2012 Jan;5(1):47-58. doi: 10.2174/1874471011205010047. PMID: 21864242.
3: Delisle MJ, Kalis B, Pourny C, Cattan A, Morel M, Valeyre J. Notre expérience de l'exploration isotopique des mélanomes par l'iodoquine marquée [Isotopic examination of melanoma with labelled iodoquine]. Bull Soc Fr Dermatol Syphiligr. 1972;79(2):163-5. French. PMID: 4657090.
4: Blois MS. Melanin binding properties of iodoquine. J Invest Dermatol. 1968 Mar;50(3):250-3. PMID: 5644898.
5: Moretti JL, Le Menn R, Veyret V, Beylot J, Amouretti M, Bioulac P, Blanquet P. Utilisation de l'iodoquine I 131 dans la détection des métastases ganglionnaires d'un naevocrcinome [Use of I 131 iodoquine in the diagnosis of lymph-node metastasis of a naevocarcinoma]. Sem Hop. 1972 Apr 20;48(19):1367-70. French. PMID: 4339359.
6: Blanquet P, Le Coulant P, Texier L, Tamisier JM, Moretti JL, Safi N. Utilisation d'un nouveau vecteur iodé (iodoquine marquée) dans le diagnostic des naevo-carcinomes [Use of a new iodated vector (labelled iodoquine) in the diagnosis of nevocarcinoma]. Bord Med. 1971 Mar;4(3):719-20 passim. French. PMID: 5575617.
7: Blanquet P, Le Coulant P, Texier L, Moretti JL, Safi N, Tamisier JM, Géniaux M. Utilisation d'un nouveau vecteur iodé (iodoquine marquée) dans le diagnostic des naevo-carcinomes [Utilization of a new iodized vector (labelled iodoquine) in the diagnosis of nevocarcinoma]. Bull Soc Fr Dermatol Syphiligr. 1970 Jul;77(1):6-10. French. PMID: 5430043.
8: Huriez C, Swynghedauw J, Bergoend H. Notre expérience de l'utilisation de l'iodoquine marquée dans le diagnostic des naevocarcinomes [Use of labelled iodoquine in the diagnosis of nevocarcinoma]. Bull Soc Fr Dermatol Syphiligr. 1972;79(2):159-62. French. PMID: 4657089.
9: Lin AJ, Loo TL. Synthesis and antitumor activity of halogen-substituted 4-(3,3-dimethyl-1-triazeno)quinolines. J Med Chem. 1978 Mar;21(3):268-72. doi: 10.1021/jm00201a006. PMID: 628002.
