LG-120753 is a selective antagonist of the glucocorticoid receptor, primarily studied for its potential applications in treating conditions related to excessive glucocorticoid activity, such as Cushing’s syndrome and other disorders associated with cortisol overproduction. Its mechanism involves binding to the glucocorticoid receptor, preventing the receptor's activation by cortisol, and thereby modulating the physiological effects of glucocorticoids. By inhibiting this receptor, LG-120753 can help reduce inflammation and suppress the catabolic effects of glucocorticoids, such as muscle wasting and bone loss. The compound is being investigated for its role in developing therapies for conditions involving chronic stress and dysregulated cortisol signaling.
MedKoo Cat#: 145974
Name: LG-120753
CAS#: 179894-84-9
Chemical Formula: C19H18N2
Exact Mass: 274.1500
Molecular Weight: 274.37
Elemental Analysis: C, 83.18; H, 6.61; N, 10.21
The following data is based on the product molecular weight 274.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
