SP-647 is a small-molecule drug that acts as an inhibitor of the chemokine receptor CCR2. It has shown potential in the treatment of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis, by blocking the recruitment of inflammatory cells to affected areas. SP-647 works by selectively binding to CCR2, preventing its activation by chemokines like MCP-1, thus reducing the inflammatory response. This mechanism may help alleviate symptoms in conditions where chronic inflammation plays a central role, offering a novel approach to managing these diseases.
MedKoo Cat#: 145968
Name: SP-647
CAS#: 51419-60-4
Chemical Formula: C22H26Cl2N6
Exact Mass: 444.1600
Molecular Weight: 445.39
Elemental Analysis: C, 59.33; H, 5.88; Cl, 15.92; N, 18.87
The following data is based on the product molecular weight 445.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
