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MedKoo Cat#: 145962 | Name: Florquinitau

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Florquinitau is a biochemical.

Chemical Structure

Florquinitau
Florquinitau
CAS#1841078-87-2

Theoretical Analysis

MedKoo Cat#: 145962

Name: Florquinitau

CAS#: 1841078-87-2

Chemical Formula: C16H11FN4

Exact Mass: 278.1000

Molecular Weight: 278.29

Elemental Analysis: C, 69.06; H, 3.98; F, 6.83; N, 20.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Florquinitau; MK-6240; MK 6240; MK6240;
IUPAC/Chemical Name
6-fluoro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine
InChi Key
KAXAUWZJVWGFDO-UHFFFAOYSA-N
InChi Code
1S/C16H11FN4/c17-13-2-1-11-8-20-15(7-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
SMILES Code
NC1=C(F)C=CC2=C1C=C(N=C2)N3C=CC4=C3C=NC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 278.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rea Reyes RE, Cody KA, Wilson RE, Zetterberg H, Chin NA, Jonaitis EM, Bahr M, Mandel O, Wintlend M, Bendlin BB, Okonkwo OC, Clark LR, Zammit M, Asthana S, Christian BT, Betthauser TJ, Eisenmenger L, Langhough RE, Johnson SC. Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease. Alzheimers Dement. 2025 Feb;21(2):e14406. doi: 10.1002/alz.14406. Epub 2024 Nov 19. PMID: 39560002; PMCID: PMC11848396. 2: Varlow C, Vasdev N. Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy. J Nucl Med. 2023 Mar;64(3):460-465. doi: 10.2967/jnumed.122.264404. Epub 2022 Sep 15. PMID: 36109185; PMCID: PMC10071800. 3: Knight AC, Morrone CD, Varlow C, Yu WH, McQuade P, Vasdev N. Head-to-Head Comparison of Tau-PET Radioligands for Imaging TDP-43 in Post-Mortem ALS Brain. Mol Imaging Biol. 2023 Jun;25(3):513-527. doi: 10.1007/s11307-022-01779-1. Epub 2022 Oct 18. PMID: 36258099. 4: Salman Y, Gérard T, Huyghe L, Colmant L, Quenon L, Malotaux V, Ivanoiu A, Lhommel R, Dricot L, Hanseeuw BJ; Alzheimer's Disease Neuroimaging Initiative. Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease. Alzheimers Dement. 2024 Oct;20(10):7205-7219. doi: 10.1002/alz.14235. Epub 2024 Sep 10. PMID: 39254209; PMCID: PMC11485073. 5: Shuping JL, Matthews DC, Adamczuk K, Scott D, Rowe CC, Kreisl WC, Johnson SC, Lukic AS, Johnson KA, Rosa-Neto P, Andrews RD, Van Laere K, Cordes L, Ward L, Wilde CL, Barakos J, Purcell DD, Devanand DP, Stern Y, Luchsinger JA, Sur C, Price JC, Brickman AM, Klunk WE, Boxer AL, Mathotaarachchi SS, Lao PJ, Evelhoch JL. Development, initial validation, and application of a visual read method for [18F]MK-6240 tau PET. Alzheimers Dement (N Y). 2023 Feb 12;9(1):e12372. doi: 10.1002/trc2.12372. PMID: 36873926; PMCID: PMC9983143.

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