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MedKoo Cat#: 145894 | Name: Gostatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gostatin is a small molecule inhibitor that has been studied for its potential to modulate cellular processes related to cancer and metabolism. It primarily works by inhibiting the function of a protein called SREBP (Sterol Regulatory Element-Binding Protein), which plays a crucial role in lipid metabolism and the synthesis of cholesterol. By blocking SREBP activity, gostatin can reduce lipid synthesis and disrupt the growth of cancer cells, particularly in cancers that are dependent on lipid biosynthesis. Its applications are being explored in cancer research and metabolic disorders, as it holds promise as a therapeutic agent for targeting metabolic pathways in diseases such as cancer and obesity.

Chemical Structure

Gostatin
Gostatin
CAS#78416-84-9

Theoretical Analysis

MedKoo Cat#: 145894

Name: Gostatin

CAS#: 78416-84-9

Chemical Formula: C8H10N2O5

Exact Mass: 214.0600

Molecular Weight: 214.18

Elemental Analysis: C, 44.86; H, 4.71; N, 13.08; O, 37.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Gostatin; Gostatine; NSC-382261; NSC382261; NSC 382261;
IUPAC/Chemical Name
5-amino-3-(carboxymethyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid
InChi Key
UXFJYSFCCBPXED-UHFFFAOYSA-N
InChi Code
1S/C8H10N2O5/c9-4-2-10-6(8(14)15)3(7(4)13)1-5(11)12/h4,10H,1-2,9H2,(H,11,12)(H,14,15)
SMILES Code
NC1CNC(C(O)=O)=C(CC(O)=O)C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 214.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lanthorn TH, Fagg GE. Gostatin blocks physiological actions and binding of acidic amino acids in rat brain. Neuropharmacology. 1989 Apr;28(4):429-32. doi: 10.1016/0028-3908(89)90041-5. PMID: 2546088. 2: Nishino T, Murao S, Wada H. Mechanism of inactivation of pyridoxal phosphate- linked aspartate transaminase by gostatin. J Biochem. 1984 May;95(5):1283-8. doi: 10.1093/oxfordjournals.jbchem.a134733. PMID: 6746607. 3: Kitagishi K, Hiromi K, Tanase S, Nagashima F, Morino Y, Nishino T, Murao S. Kinetic studies on the binding of gostatin, a suicide substrate for aspartate aminotransferase, with the isoenzymes from porcine heart mitochondria and cytosol. J Biochem. 1988 Apr;103(4):585-8. doi: 10.1093/oxfordjournals.jbchem.a122311. PMID: 3170501. 4: Arenas Díaz G, Martínez-Rodriguez R. Action of gostatin and beta-methylene- DL-aspartate (BMA) on cerebellar aspartate aminotransferase (AAT) histochemical reaction. Cell Mol Biol. 1987;33(4):477-82. PMID: 3664557. 5: Rowe AF, Lowe PN. Modulation of amino acid and 2-oxo acid pools in Trichomonas vaginalis by aspartate aminotransferase inhibitors. Mol Biochem Parasitol. 1986 Oct;21(1):17-24. doi: 10.1016/0166-6851(86)90074-5. PMID: 2877395. 6: Lowe PN, Rowe AF. Aspartate: 2-oxoglutarate aminotransferase from trichomonas vaginalis. Identity of aspartate aminotransferase and aromatic amino acid aminotransferase. Biochem J. 1985 Dec 15;232(3):689-95. doi: 10.1042/bj2320689. PMID: 3879173; PMCID: PMC1152940. 7: Martinez-Rodriguez R, Najera ML, Gragera RR, Tonda A, Gonzalez-Romero FJ, Fernandez AM, Alonso MJ, Lopez-Bravo A. Axonal and non-axonal immunolocalization of cytosolic aspartate aminotransferase (cAATase), GABA and glutamic acid decarboxylase (GAD) in the rat cochlear nucleus. J Hirnforsch. 1992;33(6):637-44. PMID: 1494041.