MedKoo Cat#: 145885 | Name: Cotylenol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cotylenol is a bioactive compound derived from certain plants, particularly those in the Corydalis genus, and is known for its analgesic and anti-inflammatory effects. It works by interacting with the central nervous system and modulating pain perception through opioid receptor activation, which helps to alleviate pain and reduce inflammation. The mechanism of cotylenol involves inhibiting pain signal transmission in the nervous system, making it a potential candidate for treating conditions such as chronic pain or arthritis.

Chemical Structure

Cotylenol
Cotylenol
CAS#41059-90-9

Theoretical Analysis

MedKoo Cat#: 145885

Name: Cotylenol

CAS#: 41059-90-9

Chemical Formula: C21H34O4

Exact Mass: 350.2500

Molecular Weight: 350.50

Elemental Analysis: C, 71.96; H, 9.78; O, 18.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cotylenol;
IUPAC/Chemical Name
(1R,3aS,4R,5R,6R,9aR,E)-7-isopropyl-1-(methoxymethyl)-4,9a-dimethyl-1,2,3,3a,4,5,6,8,9,9a-decahydrodicyclopenta[a,d][8]annulene-1,5,6-triol
InChi Key
AKKFAKCBIIOLLX-LQQINCHMSA-N
InChi Code
1S/C21H34O4/c1-12(2)14-6-8-20(4)10-16-15(7-9-21(16,24)11-25-5)13(3)18(22)19(23)17(14)20/h10,12-13,15,18-19,22-24H,6-9,11H2,1-5H3/b16-10+/t13-,15+,18-,19-,20-,21+/m1/s1
SMILES Code
[H][C@@]12CC[C@](O)(COC)C1=C[C@@]3(C)CCC(C(C)C)=C3[C@@H](O)[C@H](O)[C@@H]2C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 350.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ting SI, Snelson DW, Huffman TR, Kuroo A, Sato R, Shenvi RA. Synthesis of (-)-Cotylenol, a 14-3-3 Molecular Glue Component. J Am Chem Soc. 2023 Sep 20;145(37):20634-20645. doi: 10.1021/jacs.3c07849. Epub 2023 Sep 8. PMID: 37683289; PMCID: PMC11022164. 2: Snelson DW, Ting SI, Shenvi RA. Contrasteric Glycosylations of Cotylenol and 1,2-Diols by Virtual Linker Selection. J Am Chem Soc. 2025 Jan 8;147(1):1327-1333. doi: 10.1021/jacs.4c15719. Epub 2024 Dec 17. PMID: 39688146. 3: Tanifuji R, Oguri H. Chemo-enzymatic total synthesis: current approaches toward the integration of chemical and enzymatic transformations. Beilstein J Org Chem. 2024 Jul 23;20:1693-1712. doi: 10.3762/bjoc.20.151. PMID: 39076288; PMCID: PMC11285072. 4: Evidente A, Andolfi A, Fiore M, Boari A, Vurro M. Stimulation of Orobanche ramosa seed germination by fusicoccin derivatives: a structure-activity relationship study. Phytochemistry. 2006 Jan;67(1):19-26. doi: 10.1016/j.phytochem.2005.10.010. Epub 2005 Nov 28. PMID: 16310229. 5: Cüppers H. Der Schnupfen und seine Behandlung mit Co-Tylenol [Rhinitis and it's therapy with Co-Tylenol]. Schweiz Rundsch Med Prax. 1972 Apr 25;61(17):565-7. German. PMID: 4337824. 6: Peter M. Die Behandlung von Erkältungskrankheiten mit einem neuen Medikament --Co-Tylenol [Treatment of common cold with a new drug Co-Tylenol]. Schweiz Rundsch Med Prax. 1972 May 16;61(20):682-3. German. PMID: 4563620.