Neostigmine is a reversible acetylcholinesterase inhibitor, primarily used in the treatment of myasthenia gravis, a neuromuscular disorder characterized by muscle weakness. It works by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine at synapses, thereby increasing the levels of acetylcholine and improving neuromuscular transmission. This action helps enhance muscle strength and reduce the symptoms of muscle fatigue. Additionally, neostigmine is used to reverse the effects of neuromuscular blocking agents used during surgery, improving muscle function post-operation.
MedKoo Cat#: 145881
Name: Neostigmine
CAS#: 16088-19-0
Chemical Formula: C11H16N2O2
Exact Mass: 208.1200
Molecular Weight: 208.26
Elemental Analysis: C, 63.44; H, 7.74; N, 13.45; O, 15.36
The following data is based on the product molecular weight 208.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
