AS-602868 is a selective inhibitor of the enzyme histone deacetylase 6 (HDAC6), which plays a key role in regulating cellular processes such as protein degradation, microtubule dynamics, and cell motility. By inhibiting HDAC6, AS-602868 can enhance the acetylation of tubulin and other proteins, leading to the disruption of cancer cell motility and promoting tumor cell death. This compound has been studied for its potential application in cancer therapy, particularly in treating hematologic cancers and solid tumors by targeting cancer cell migration and survival mechanisms. Its mechanism involves altering cellular protein acetylation levels, which impacts cell cycle regulation, apoptosis, and response to stress.
MedKoo Cat#: 145879
Name: AS-602868
CAS#: 219773-55-4
Chemical Formula: C18H14N4O3S
Exact Mass: 366.0800
Molecular Weight: 366.40
Elemental Analysis: C, 59.01; H, 3.85; N, 15.29; O, 13.10; S, 8.75
The following data is based on the product molecular weight 366.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
