Diacetamide | CAS#625-77-4 | biochemical

MedKoo Cat#: 145871 | Name: Diacetamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diacetamide is an organic compound primarily used as an intermediate in the synthesis of various chemicals, including agrochemicals and pharmaceuticals. It functions as a versatile reagent in chemical reactions, often involved in the formation of amides or as a stabilizer in industrial applications. Its mechanism of action typically centers on its ability to donate acetyl groups, which can modify other molecules in biochemical or synthetic processes.

Chemical Structure

Diacetamide

CAS#625-77-4

Theoretical Analysis

MedKoo Cat#: 145871

Name: Diacetamide

CAS#: 625-77-4

Chemical Formula: C4H7NO2

Exact Mass: 101.0500

Molecular Weight: 101.11

Elemental Analysis: C, 47.52; H, 6.98; N, 13.85; O, 31.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Diacetamide; NSC-405639; NSC405639; NSC 405639;

IUPAC/Chemical Name

N-acetylacetamide

InChi Key

ZSBDPRIWBYHIAF-UHFFFAOYSA-N

InChi Code

1S/C4H7NO2/c1-3(6)5-4(2)7/h1-2H3,(H,5,6,7)

SMILES Code

CC(=O)NC(C)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 101.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang F, Liu Y, Ma KQ, Yan H, Luo Y, Wu FC, Yang CT, Hu S, Peng SM. Highly selective extraction of uranium from wastewater using amine-bridged diacetamide- functionalized silica. J Hazard Mater. 2022 Aug 5;435:129022. doi: 10.1016/j.jhazmat.2022.129022. Epub 2022 Apr 27. PMID: 35500348. 2: Cai HX, Wu WN. 2,2'-Dichloro-N,N'-[1,3-phenyl-enebis(methyl-ene)]diacetamide. Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o933. doi: 10.1107/S1600536812008653. Epub 2012 Mar 3. PMID: 22589996; PMCID: PMC3343915. 3: Wang JL. N,N'-Di-8-quinolyl-2,2'-(o-phenyl-ene-di-oxy)diacetamide. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 23;65(Pt 11):o2844. doi: 10.1107/S1600536809041312. PMID: 21578434; PMCID: PMC2971241. 4: Li XF, An Y, Huang QH, Wen YH. N,N-Bis(quinolin-8-yl)-2,2'-[(1,3,4-thia- diazole-2,5-di-yl)bis-(sulfanedi-yl)]diacetamide monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3291. doi: 10.1107/S1600536811047222. Epub 2011 Nov 12. PMID: 22199794; PMCID: PMC3238945. 5: Sasaki Y, Nakase M, Kaneko M, Kobayashi T, Takeshita K, Matsumiya M. Preliminary studies of XANES and DFT calculation of Ru extraction by imino- diacetamide and related compounds. Anal Sci. 2024 Feb;40(2):335-339. doi: 10.1007/s44211-023-00453-y. Epub 2023 Nov 7. PMID: 37934340. 6: Salarinejad S, Seyfi S, Hayashi S, Moghimi S, Toolabi M, Taslimi P, Firoozpour L, Usui T, Foroumadi A. Design, synthesis, and biological evaluation of new biaryl derivatives of cycloalkyl diacetamide bearing chalcone moiety as type II c-MET kinase inhibitors. Mol Divers. 2024 Dec;28(6):4167-4180. doi: 10.1007/s11030-024-10807-x. Epub 2024 Mar 11. PMID: 38466553. 7: Southcott L, Whetter JN, Wharton L, Patrick BO, Zarschler K, Kubeil M, Stephan H, Jaraquemada-Peláez MG, Orvig C. Bis(amido)bis(oxinate)diamine Ligands for theranostic radiometals. J Inorg Biochem. 2022 Jun;231:111789. doi: 10.1016/j.jinorgbio.2022.111789. Epub 2022 Mar 12. PMID: 35305407. 8: Wang W, Huang Y, Tang N. N,N'-Dibenzyl-2,2'-[(1,3,4-oxadiazole-2,5-di- yl)bis-(o-phenyl-eneoxy)]diacet-amide. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 31;64(Pt 11):o2237. doi: 10.1107/S1600536808033904. PMID: 21581091; PMCID: PMC2959583. 9: Li Y, Qi Y, Fang Y, Gao H, Zhang H. Design, Synthesis, and Biological Evaluation of 4-Arylamino Pyrimidine Derivatives as FAK Inhibitors and Tumor Radiotracers. Mol Pharm. 2022 Jul 4;19(7):2471-2482. doi: 10.1021/acs.molpharmaceut.2c00180. Epub 2022 Apr 28. PMID: 35481371. 10: Dau PV, Zhang Z, Dau PD, Gibson JK, Rao L. Thermodynamic study of the complexation between Nd(3+) and functionalized diacetamide ligands in solution. Dalton Trans. 2016 Jul 26;45(30):11968-75. doi: 10.1039/c6dt01694d. PMID: 27222301. 11: Nandini G, Sathyanarayana DN. Ab initio studies of solvent effect on molecular conformation and vibrational spectra of diacetamide. Spectrochim Acta A Mol Biomol Spectrosc. 2004 Apr;60(5):1115-26. doi: 10.1016/j.saa.2003.07.008. PMID: 15084331. 12: Nithya K, Muthukumar C, Biswas B, Alharbi NS, Kadaikunnan S, Khaled JM, Dhanasekaran D. Desert actinobacteria as a source of bioactive compounds production with a special emphases on Pyridine-2,5-diacetamide a new pyridine alkaloid produced by Streptomyces sp. DA3-7. Microbiol Res. 2018 Mar;207:116-133. doi: 10.1016/j.micres.2017.11.012. Epub 2017 Nov 21. PMID: 29458846. 13: Gao Y, Dau PV, Parker BF, Arnold J, Melchior A, Zhang Z, Rao L. Complexation of NpO2+ with Amine-Functionalized Diacetamide Ligands in Aqueous Solution: Thermodynamic, Structural, and Computational Studies. Inorg Chem. 2018 Jun 18;57(12):6965-6972. doi: 10.1021/acs.inorgchem.8b00654. Epub 2018 Jun 5. PMID: 29870237. 14: Murugaiyan K, Murali VP, Tamura H, Furuike T, Rangasamy J. Overview of chitin dissolution, hydrogel formation and its biomedical applications. J Biomater Sci Polym Ed. 2024 Dec 20:1-32. doi: 10.1080/09205063.2024.2442181. Epub ahead of print. PMID: 39704399. 15: Makrlík E, Vaňura P, Selucký P. Synergistic Extraction of Strontium into Nitrobenzene by Using Hydrogen Dicarbollylcobaltate and N,N,N´,N´-Tetracyclohexyl-oxybis(o-phenyleneoxy) diacetamide. Acta Chim Slov. 2012 Mar;59(1):189-93. PMID: 24061190. 16: Dau PV, Zhang Z, Gao Y, Parker BF, Dau PD, Gibson JK, Arnold J, Tolazzi M, Melchior A, Rao L. Thermodynamic, Structural, and Computational Investigation on the Complexation between UO22+ and Amine-Functionalized Diacetamide Ligands in Aqueous Solution. Inorg Chem. 2018 Feb 19;57(4):2122-2131. doi: 10.1021/acs.inorgchem.7b02971. Epub 2018 Feb 2. PMID: 29394057. 17: QUAGLIARIELLO E, AURICCHIO S, RINALDI E, RUBINO A. Effect of diphosphopyridine nucleotide on the inhibition of rat liver 3-hydroxyanthranilic-acid oxidase by 2-acetylaminofluorene and N-2-fluorenyl- diacetamide. Nature. 1958 Dec 20;182(4651):1744. doi: 10.1038/1821744a0. PMID: 13622647. 18: Tang M, Shen J, Zhang F, Zhao Y, Gan T, Zeng W, Li R, Wang D, Han B, Liu Z. Upcycling of Polyamide Wastes to Tertiary Amines Using Mo Single Atoms and Rh Nanoparticles. Angew Chem Int Ed Engl. 2025 Jan 27;64(5):e202416436. doi: 10.1002/anie.202416436. Epub 2024 Nov 12. PMID: 39417695. 19: Arıkan CC, Kulabaş N, Küçükgüzel İ. Synthesis and standardization of an impurity of acetaminophen, development and validation of liquid chromatographic method. J Pharm Biomed Anal. 2023 Jan 20;223:115123. doi: 10.1016/j.jpba.2022.115123. Epub 2022 Oct 26. PMID: 36327580. 20: TAUTU P, STANESCU L. EXPERIMENTAL INVESTIGATIONS ON THE TOXICITY AND ANTITUMORAL ACTIVITY OF CERTAIN NOVOCAIN, URETHAN, SULPHANILUREA, TETRAHYDRONAPHTHYLAMINE AND DIACETAMIDE DERIVATIVES. Acta Unio Int Contra Cancrum. 1964;20:96-9. PMID: 14151992.