Synonym
Xanthevodine; NSC-94652; NSC94652; NSC 94652;
IUPAC/Chemical Name
4,11-dimethoxy-[1,3]dioxolo[4,5-b]acridin-10(5H)-one
InChi Key
XKWQECWFQVTROA-UHFFFAOYSA-N
InChi Code
1S/C16H13NO5/c1-19-13-10-11(14(20-2)16-15(13)21-7-22-16)17-9-6-4-3-5-8(9)12(10)18/h3-6H,7H2,1-2H3,(H,17,18)
SMILES Code
COC1=C2OCOC2=C(OC)C3=C1NC4=C(C=CC=C4)C3=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
299.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Menezes APJ, Silva MLD, Pereira WL, Costa GP, Horta AL, Mendonça AAS, Carneiro ACA, Souza DMS, Novaes RD, Teixeira RR, Talvani A. In vitro tripanocidal effect of 1,8-dioxooctahydroxanthenes (xanthenodiones) and tetraketones and improvement of cardiac parameters in vivo. J Glob Antimicrob Resist. 2020 Sep;22:466-476. doi: 10.1016/j.jgar.2020.04.005. Epub 2020 May 14. PMID: 32417591.
2: Rodrigues FAF, Teixeira RR, Bazzolli DMS, da Silva GC, Fontes PP, Diaz-Muñoz G, Rossi CC, Diaz MAN. Two novel synthetic xanthenodiones as antimicrobial, anti-adhesive and antibiofilm compounds against methicillin resistant Staphylococcus aureus. Braz J Microbiol. 2024 Jun;55(2):1243-1249. doi: 10.1007/s42770-024-01305-1. Epub 2024 Mar 29. PMID: 38551766; PMCID: PMC11153428.
3: Poly da Silva ÍE, Lopes da Silva M, Dias RS, Santos EG, Brangioni de Paula MC, Silva de Oliveira A, Costa da Silveira Oliveira AF, Marques de Oliveira F, Canedo da Silva C, Teixeira RR, Oliveira de Paula S. Xanthenedione (and intermediates involved in their synthesis) inhibit Zika virus migration to the central nervous system in murine neonatal models. Microbes Infect. 2020 Oct;22(9):489-499. doi: 10.1016/j.micinf.2020.04.007. Epub 2020 Apr 27. PMID: 32353601.
4: Fernandes LS, da Silva ML, Dias RS, da S Lucindo MS, da Silva ÍEP, Silva CC, Teixeira RR, de Paula SO. Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus. Viruses. 2021 Oct 21;13(11):2123. doi: 10.3390/v13112123. PMID: 34834929; PMCID: PMC8625987.
