IKP-104 | CAS#114231-14-0 | biochemical

MedKoo Cat#: 145827 | Name: IKP-104

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IKP-104 is a chemical compound that is being studied for its pharmacological properties. It is a prodrug that converts into an active form, known as IKP-101, in the body. IKP-104 has shown promise in the research of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease.

Chemical Structure

IKP-104

CAS#114231-14-0

Theoretical Analysis

MedKoo Cat#: 145827

Name: IKP-104

CAS#: 114231-14-0

Chemical Formula: C26H21ClFNO3

Exact Mass: 449.1200

Molecular Weight: 449.91

Elemental Analysis: C, 69.41; H, 4.70; Cl, 7.88; F, 4.22; N, 3.11; O, 10.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IKP-104; IKP104; IKP 104;

IUPAC/Chemical Name

1-(2-chloro-3,5-dimethoxyphenyl)-2-(4-fluorophenyl)-3-methyl-6-phenylpyridin-4(1H)-one

InChi Key

MYSNSNGSKLLDBP-UHFFFAOYSA-N

InChi Code

1S/C26H21ClFNO3/c1-16-23(30)15-21(17-7-5-4-6-8-17)29(26(16)18-9-11-19(28)12-10-18)22-13-20(31-2)14-24(32-3)25(22)27/h4-15H,1-3H3

SMILES Code

COC1=CC(N2C(=CC(=O)C(C)=C2C3=CC=C(F)C=C3)C4=CC=CC=C4)=C(Cl)C(OC)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 449.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mizuhashi F, Murata K, Kitagaki T, Tomita I. Interaction of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, with microtubule proteins. Jpn J Cancer Res. 1992 Feb;83(2):211-8. doi: 10.1111/j.1349-7006.1992.tb00088.x. PMID: 1556002; PMCID: PMC5918791. 2: Mizuhashi F, Murata K, Kitagaki T, Tomita I. Effects of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, on cytoskeletal microtubules of cultured tumor cells. Jpn J Cancer Res. 1991 Dec;82(12):1442-7. doi: 10.1111/j.1349-7006.1991.tb01818.x. PMID: 1778768; PMCID: PMC5918355. 3: Khan IA, Tomita I, Mizuhashi F, Ludueña RF. Differential interaction of tubulin isotypes with the antimitotic compound IKP-104. Biochemistry. 2000 Aug 1;39(30):9001-9. doi: 10.1021/bi000331o. PMID: 10913313. 4: Mizuhashi F, Murata K, Kitagaki T, Nezu M, Sano M, Tomita I. Antitumor activities of IKP-104, a 4(1H)-pyrizinone derivative, on cultured and implanted tumors. Jpn J Cancer Res. 1990 Dec;81(12):1300-6. doi: 10.1111/j.1349-7006.1990.tb02694.x. PMID: 2125999; PMCID: PMC5918018. 5: Chaudhuri AR, Tomita I, Mizuhashi F, Murata K, Potenziano JL, Ludueña RF. IKP104-induced decay of tubulin: role of the A-ring binding site of colchicine. Biochemistry. 1998 Dec 8;37(49):17157-62. doi: 10.1021/bi980812w. PMID: 9860828. 6: Prasad V, Chaudhuri AR, Curcio M, Tomita I, Mizuhashi F, Murata K, Ludueña RF. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8. doi: 10.1007/BF02780968. PMID: 9853681. 7: Chaudhuri AR, Tomita I, Mizuhashi F, Murata K, Ludueña RF. Tubulin stability and decay: mediation by two distinct classes of IKP104-binding sites. J Protein Chem. 1998 May;17(4):303-9. doi: 10.1023/a:1022579930546. PMID: 9619583. 8: Luduena RF, Roach MC, Prasad V, Chaudhuri AR, Tomita I, Mizuhashi F, Murata K. Interaction of bovine brain tubulin with the 4(1H)-pyrizinone derivative IKP104, an antimitotic drug with a complex set of effects on the conformational stability of the tubulin molecule. Biochemistry. 1995 Dec 5;34(48):15751-9. doi: 10.1021/bi00048a020. PMID: 7495806. 9: Chaudhuri AR, Tomita I, Mizuhashi F, Murata K, Ludueña RF. Distinct and overlapping binding sites for IKP104 and vinblastine on tubulin. J Protein Chem. 1998 Oct;17(7):685-90. doi: 10.1007/BF02780971. PMID: 9853684.