Synonym
Vicanicin; NSC-289106; NSC289106; NSC 289106;
IUPAC/Chemical Name
2,7-dichloro-3-hydroxy-8-methoxy-1,4,6,9-tetramethyl-11H-dibenzo[b,e][1,4]dioxepin-11-one
InChi Key
DJIUVCGPONSSSV-UHFFFAOYSA-N
InChi Code
1S/C18H16Cl2O5/c1-6-10-14(8(3)13(21)11(6)19)24-16-7(2)12(20)15(23-5)9(4)17(16)25-18(10)22/h21H,1-5H3
SMILES Code
COC1=C(Cl)C(C)=C2OC3=C(C(C)=C(Cl)C(O)=C3C)C(=O)OC2=C1C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
383.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Russo A, Caggia S, Piovano M, Garbarino J, Cardile V. Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein. Chem Biol Interact. 2012 Jan 5;195(1):1-10. doi: 10.1016/j.cbi.2011.10.005. Epub 2011 Oct 29. PMID: 22063921.
2: Sanjaya A, Avidlyandi A, Adfa M, Ninomiya M, Koketsu M. A New Depsidone from Teloschistes flavicans and the Antileukemic Activity. J Oleo Sci. 2020 Dec 1;69(12):1591-1595. doi: 10.5650/jos.ess20209. Epub 2020 Nov 12. PMID: 33177283.
3: Do TH, Duong TH, Vu YT, Tran HP, Nguyen TT, Sichaem J, Nguyen NH, Nguyen HT, Pham DD. Alpha-glucosidase inhibitory compounds from Vietnamese lichen Usnea baileyi: in vitro and in silico aspects. RSC Adv. 2024 Oct 15;14(44):32624-32636. doi: 10.1039/d4ra04449e. PMID: 39411260; PMCID: PMC11475664.
4: Brisdelli F, Perilli M, Sellitri D, Piovano M, Garbarino JA, Nicoletti M, Bozzi A, Amicosante G, Celenza G. Cytotoxic activity and antioxidant capacity of purified lichen metabolites: an in vitro study. Phytother Res. 2013 Mar;27(3):431-7. doi: 10.1002/ptr.4739. Epub 2012 May 25. PMID: 22628260.