MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 145800 | Name: Rhetsinine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rhetsinine is a naturally occurring alkaloid found in certain plants, particularly those in the Rheum genus, such as Rheum emodi (Indian rhubarb). It has been studied for its potential pharmacological effects, including antioxidant, anti-inflammatory, and antimicrobial properties. Rhetsinine, like many other plant-derived compounds, may have traditional uses in herbal medicine, but its precise biological mechanisms and therapeutic applications are still being researched.

Chemical Structure

Rhetsinine
Rhetsinine
CAS#526-43-2

Theoretical Analysis

MedKoo Cat#: 145800

Name: Rhetsinine

CAS#: 526-43-2

Chemical Formula: C19H17N3O2

Exact Mass: 319.1300

Molecular Weight: 319.36

Elemental Analysis: C, 71.46; H, 5.37; N, 13.16; O, 10.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Rhetsinine; NSC-258315; NSC258315; NSC 258315;
IUPAC/Chemical Name
2-(2-(methylamino)benzoyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one
InChi Key
RAEOYMOPVHBBKE-UHFFFAOYSA-N
InChi Code
1S/C19H17N3O2/c1-20-15-8-4-3-7-14(15)18(23)22-11-10-13-12-6-2-5-9-16(12)21-17(13)19(22)24/h2-9,20-21H,10-11H2,1H3
SMILES Code
CNC1=CC=CC=C1C(=O)N2CCC3=C(NC4=CC=CC=C34)C2=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kato A, Yasuko H, Goto H, Hollinshead J, Nash RJ, Adachi I. Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine. 2009 Mar;16(2-3):258-61. doi: 10.1016/j.phymed.2007.04.008. Epub 2007 May 10. PMID: 17498942. 2: Su XL, Xu S, Shan Y, Yin M, Chen Y, Feng X, Wang QZ. Three new quinazolines from Evodia rutaecarpa and their biological activity. Fitoterapia. 2018 Jun;127:186-192. doi: 10.1016/j.fitote.2018.02.003. Epub 2018 Feb 14. PMID: 29454021. 3: Minehira D, Takeda D, Urata H, Kato A, Adachi I, Wang X, Matsuya Y, Sugimoto K, Takemura M, Endo S, Matsunaga T, Hara A, Koseki J, Narukawa K, Hirono S, Toyooka N. Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1. Bioorg Med Chem. 2012 Jan 1;20(1):356-67. doi: 10.1016/j.bmc.2011.10.073. Epub 2011 Nov 3. PMID: 22104435. 4: Yamazaki M, Kawana T. [Isolation of hydroxyevodiamine (rhetsinine) from the fruits of Evodia rutaecarpa Hook fil. et Thomson]. Yakugaku Zasshi. 1967 May;87(5):608-10. Japanese. doi: 10.1248/yakushi1947.87.5_608. PMID: 5624509. 5: Zhou Z, Wang D, Luo D, Zhou Z, Liu W, Zeng W, Dinnyés A, Xiong YL, Sun Q. Non-covalent binding of chlorogenic acid to myofibrillar protein improved its bio-functionality properties and metabolic fate. Food Chem. 2024 May 15;440:138208. doi: 10.1016/j.foodchem.2023.138208. Epub 2023 Dec 15. PMID: 38159322.