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MedKoo Cat#: 145797 | Name: Methoxyurea

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methoxyurea is a chemotherapy drug used primarily in the treatment of certain cancers, particularly myeloproliferative disorders like chronic myelogenous leukemia (CML). It works by inhibiting the growth of cancer cells by interfering with DNA synthesis, which prevents cell division. Methoxyurea is similar in action to other chemotherapy agents like hydroxyurea but has a slightly different chemical structure.

Chemical Structure

Methoxyurea
Methoxyurea
CAS#3272-27-3

Theoretical Analysis

MedKoo Cat#: 145797

Name: Methoxyurea

CAS#: 3272-27-3

Chemical Formula: C2H6N2O2

Exact Mass: 90.0400

Molecular Weight: 90.08

Elemental Analysis: C, 26.67; H, 6.71; N, 31.10; O, 35.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Methoxyurea; NSC40355; NSC-40355; NSC 40355;
IUPAC/Chemical Name
1-methoxyurea
InChi Key
JOHLTMWXHJLNDE-UHFFFAOYSA-N
InChi Code
1S/C2H6N2O2/c1-6-4-2(3)5/h1H3,(H3,3,4,5)
SMILES Code
CONC(N)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 90.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Westphal D, Lucas K, Hilbig V, Mechler U, Piasecki A. Biotransformation von Monolinuron (N-(4-Chlorphenyl)-N'-methyl-N'-methoxyharnstoff) in der isoliert perfundierten Hühnerleber [Biotransformation of monolinuron (N-(4-chlorophenyl)-N'-methyl-N'methoxyurea) in isolated perfused chicken liver]. Food Chem Toxicol. 1984 Jul;22(7):521-8. German. doi: 10.1016/0278-6915(84)90221-7. PMID: 6540228. 2: Miwa K, Hitaka T, Imada T, Sasaki S, Yoshimatsu M, Kusaka M, Tanaka A, Nakata D, Furuya S, Endo S, Hamamura K, Kitazaki T. Discovery of 1-{4-[1-(2,6-difluorob enzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-t etrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin- releasing hormone receptor. J Med Chem. 2011 Jul 28;54(14):4998-5012. doi: 10.1021/jm200216q. Epub 2011 Jun 23. PMID: 21657270. 3: Ma Y, Pedersen M, Vinggaard AM. In vitro antiandrogenic effects of the herbicide linuron and its metabolites. Chemosphere. 2024 Feb;349:140773. doi: 10.1016/j.chemosphere.2023.140773. Epub 2023 Nov 22. PMID: 38000554. 4: Anfossi P, Roncada P, Stracciari GL, Montana M, Pasqualucci C, Montesissa C. Toxicokinetics and metabolism of linuron in rabbit: in vivo and in vitro studies. Xenobiotica. 1993 Oct;23(10):1113-23. doi: 10.3109/00498259309059426. PMID: 8259693. 5: Weinberger M, Bollag JM. Degradation of chlorbromuron and related compounds by the fungus Rhizoctonia solani. Appl Microbiol. 1972 Nov;24(5):750-4. doi: 10.1128/am.24.5.750-754.1972. PMID: 4640737; PMCID: PMC380657. 6: Sasaki S, Cho N, Nara Y, Harada M, Endo S, Suzuki N, Furuya S, Fujino M. Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor. J Med Chem. 2003 Jan 2;46(1):113-24. doi: 10.1021/jm020180i. PMID: 12502365. 7: Shishkin OV, Shtamburg VG, Zubatyuk RI, Olefir DA, Tsygankov AV, Prosyanik AV, Mazepa AV, Kostyanovsky RG. Chiral ureas with two electronegative substituents at 1-N: an unusual case of coexisting pyramidal and almost planar 1-N atoms in the same crystal. Chirality. 2009 Jul;21(7):642-7. doi: 10.1002/chir.20668. PMID: 18979531. 8: Escuderos-Morenas ML, Santos-Delgado MJ, Rubio-Barroso S, Polo-Díez LM. Direct determination of monolinuron, linuron and chlorbromuron residues in potato samples by gas chromatography with nitrogen-phosphorus detection. J Chromatogr A. 2003 Sep 5;1011(1-2):143-53. doi: 10.1016/s0021-9673(03)01139-7. PMID: 14518771.