NU227326 | IDO1 PROTAC

MedKoo Cat#: 128455 | Name: NU227326

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NU227326 is a highly potent IDO1 PROTAC (DC50 = 4.5 nM) suitable for further studies in GBM and other human cancers.

Chemical Structure

NU227326

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128455

Name: NU227326

CAS#: N/A

Chemical Formula: C53H61FN8O7

Exact Mass: 940.4647

Molecular Weight: 941.12

Elemental Analysis: C, 67.64; H, 6.53; F, 2.02; N, 11.91; O, 11.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NU227326; NU-227326; NU 227326

IUPAC/Chemical Name

(2R)-N-(3-((1-(2-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)piperidin-1-yl)acetyl)piperidin-4-yl)oxy)phenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide

InChi Key

LDFDXTNMCGLUMQ-CTXDKFKBSA-N

InChi Code

InChI=1S/C53H61FN8O7/c1-33(34-5-7-35(8-6-34)42-15-20-55-46-12-9-36(54)29-44(42)46)50(65)56-37-3-2-4-41(30-37)69-40-18-23-61(24-19-40)49(64)32-58-21-16-38(17-22-58)59-25-27-60(28-26-59)39-10-11-43-45(31-39)53(68)62(52(43)67)47-13-14-48(63)57-51(47)66/h2-4,9-12,15,20,29-31,33-35,38,40,47H,5-8,13-14,16-19,21-28,32H2,1H3,(H,56,65)(H,57,63,66)/t33?,34-,35+,47?

SMILES Code

O=C1CCC(N2C(C(C=CC(N3CCN(C4CCN(CC(N5CCC(OC6=CC=CC(NC([C@H](C)[C@]7([H])CC[C@@](C8=C9C(C=CC(F)=C9)=NC=C8)([H])CC7)=O)=C6)CC5)=O)CC4)CC3)=C%10)=C%10C2=O)=O)C(N1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 941.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Monsen PJ, Bommi PV, Grigorescu AA, Lauing KL, Mao Y, Berardi P, Zhai L, Ojo O, Penco-Campillo M, Koch T, Egozi M, Jha SV, Dunne SF, Jiang H, Song G, Zhang F, Kregel S, Vaziri-Gohar A, Fanning S, Sanchez-Gomez P, Allen JM, Yamini B, Lukas RV, Wainwright DA, Schiltz GE. Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). bioRxiv [Preprint]. 2025 Jan 8:2025.01.07.631731. doi: 10.1101/2025.01.07.631731. PMID: 39829781; PMCID: PMC11741391. 2: Monsen PJ, Bommi PV, Grigorescu AA, Lauing KL, Mao Y, Berardi P, Zhai L, Ojo O, Penco-Campillo M, Koch T, Egozi M, Jha S, Dunne SF, Jiang H, Song G, Zhang F, Kregel S, Vaziri-Gohar A, Fanning SW, Sanchez-Gomez P, Allen JM, Yamini B, Lukas RV, Wainwright DA, Schiltz GE. Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). J Med Chem. 2025 Feb 13. doi: 10.1021/acs.jmedchem.5c00026. Epub ahead of print. PMID: 39946350.