MedKoo Cat#: 145789 | Name: Benzalazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benzalazine is a chemical compound that belongs to the class of azines, which are organic compounds containing a nitrogen atom in a ring structure. It is a derivative of benzene and is typically used in chemical research. Benzalazine has been explored for its potential use in medicinal chemistry, especially as an intermediate in the synthesis of other bioactive compounds.

Chemical Structure

Benzalazine
Benzalazine
CAS#588-68-1

Theoretical Analysis

MedKoo Cat#: 145789

Name: Benzalazine

CAS#: 588-68-1

Chemical Formula: C14H12N2

Exact Mass: 208.1000

Molecular Weight: 208.26

Elemental Analysis: C, 80.74; H, 5.81; N, 13.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Benzalazine;
IUPAC/Chemical Name
1,2-di((E)-benzylidene)hydrazine
InChi Key
CWLGEPSKQDNHIO-JOBJLJCHSA-N
InChi Code
1S/C14H12N2/c1-3-7-13(8-4-1)11-15-16-12-14-9-5-2-6-10-14/h1-12H/b15-11+,16-12+
SMILES Code
C1=CC=C(\C=N\N=C\C2=CC=CC=C2)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 208.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Herzog R, Leuschner J. Pharmacokinetic studies of benzalazine. Arzneimittelforschung. 1994 Dec;44(12):1381-3. PMID: 7848362. 2: Fleig WE, Laudage G, Sommer H, Wellmann W, Stange EF, Riemann J. Prospective, randomized, double-blind comparison of benzalazine and sulfasalazine in the treatment of active ulcerative colitis. Digestion. 1988;40(3):173-80. doi: 10.1159/000199652. PMID: 2906888. 3: Herzog R, Leuschner J. Single and subacute local and systemic toxicity studies of benzalazine. Arzneimittelforschung. 1994 Dec;44(12):1353-6. PMID: 7848356. 4: Herzog R, Leuschner J. Twenty-six-week oral toxicity study of benzalazine in rats. Arzneimittelforschung. 1994 Dec;44(12):1357-62. PMID: 7848357. 5: Herzog R, Leuschner J. Mutagenicity studies of benzalazine. Arzneimittelforschung. 1994 Dec;44(12):1366-8. PMID: 7848359. 6: Herzog R, Leuschner J. Reproductive toxicity studies of benzalazine in rats and rabbits. Arzneimittelforschung. 1994 Dec;44(12):1368-70. PMID: 7848360. 7: Herzog R, Leuschner J. Oncogenicity studies of benzalazine in mice and rats. Arzneimittelforschung. 1994 Dec;44(12):1371-81. PMID: 7848361. 8: Herzog R, Leuschner J. Twenty-six-week oral toxicity study of benzalazine in dogs. Arzneimittelforschung. 1994 Dec;44(12):1362-5. PMID: 7848358. 9: Silva AM, Sousa RM, Jimeno ML, Blanco F, Alkorta I, Elguero J. Experimental measurements and theoretical calculations of the chemical shifts and coupling constants of three azines (benzalazine, acetophenoneazine and cinnamaldazine). Magn Reson Chem. 2008 Sep;46(9):859-64. doi: 10.1002/mrc.2272. PMID: 18636467. 10: Gyllenhaal O, Grönberg L, Vessman J. Determination of hydrazine in hydralazine by capillary gas chromatography with nitrogen-selective detection after benzaldehyde derivatization. J Chromatogr. 1990 Jul 6;511:303-15. doi: 10.1016/s0021-9673(01)93293-5. PMID: 2211915. 11: Allgayer H, Rang S, Klotz U, Böhne P, Retey J, Kruis W, Gugler R. Superoxide inhibition following different stimuli of respiratory burst and metabolism of aminosalicylates in neutrophils. Dig Dis Sci. 1994 Jan;39(1):145-51. doi: 10.1007/BF02090074. PMID: 8281849. 12: Allgayer H, Höfer P, Schmidt M, Böhne P, Kruis W, Gugler R. Superoxide, hydroxyl and fatty acid radical scavenging by aminosalicylates. Direct evaluation with electron spin resonance spectroscopy. Biochem Pharmacol. 1992 Jan 22;43(2):259-62. doi: 10.1016/0006-2952(92)90286-r. PMID: 1310851. 13: Williams DL Jr, Lindsley CW. Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5). Curr Top Med Chem. 2005;5(9):825-46. doi: 10.2174/1568026054750290. PMID: 16178729. 14: Matsui F, Robertson DL, Lovering EG. Determination of hydrazine in pharmaceuticals III: hydralazine and isoniazid using GLC. J Pharm Sci. 1983 Aug;72(8):948-51. doi: 10.1002/jps.2600720829. PMID: 6620156. 15: Noda A, Hsu KY, Aso Y, Matsuyama K, Iguchi S, Hirata M. Studies of isoniazid metabolism in isolated rat hepatocytes by mass fragmentography. J Chromatogr. 1982 Jul 9;230(2):345-52. doi: 10.1016/s0378-4347(00)80484-3. PMID: 7107780. 16: Lutz J, Augustin AJ. Ischemia reperfusion damage in the gut and its treatment with drugs of the aminosalicylic acid group. Adv Exp Med Biol. 1994;361:327-32. doi: 10.1007/978-1-4615-1875-4_52. PMID: 7597956.