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MedKoo Cat#: 145778 | Name: Deoxytopsentin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deoxytopsentin is a bisindole alkaloid. It has been studied for its potential biological activities, including cytotoxic effects. Research has focused on synthesizing analogues of deoxytopsentin to enhance its potency and selectivity against specific targets, such as methicillin-resistant Staphylococcus aureus (MRSA). Some of these analogues have demonstrated potent inhibitory activity against MRSA protein kinase, with significant selectivity for MRSA over other strains.

Chemical Structure

Deoxytopsentin
Deoxytopsentin
CAS#112515-42-1

Theoretical Analysis

MedKoo Cat#: 145778

Name: Deoxytopsentin

CAS#: 112515-42-1

Chemical Formula: C20H14N4O

Exact Mass: 326.1200

Molecular Weight: 326.36

Elemental Analysis: C, 73.61; H, 4.32; N, 17.17; O, 4.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NSC-623150; Deoxytopsentin; NSC623150; NSC 623150;
IUPAC/Chemical Name
(4-(1H-indol-3-yl)-1H-imidazol-2-yl)(1H-indol-3-yl)methanone
InChi Key
OBDUUEITYHUFCW-UHFFFAOYSA-N
InChi Code
1S/C20H14N4O/c25-19(15-10-22-17-8-4-2-6-13(15)17)20-23-11-18(24-20)14-9-21-16-7-3-1-5-12(14)16/h1-11,21-22H,(H,23,24)
SMILES Code
O=C(C1=NC(=CN1)C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 326.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Veale CG, Zoraghi R, Young RM, Morrison JP, Pretheeban M, Lobb KA, Reiner NE, Andersen RJ, Davies-Coleman MT. Synthetic analogues of the marine bisindole deoxytopsentin: potent selective inhibitors of MRSA pyruvate kinase. J Nat Prod. 2015 Mar 27;78(3):355-62. doi: 10.1021/np500755v. Epub 2014 Nov 5. PMID: 25372480. 2: Madanagopal P, Ramprabhu N, Jagadeesan R. In silico prediction and structure- based multitargeted molecular docking analysis of selected bioactive compounds against mucormycosis. Bull Natl Res Cent. 2022;46(1):24. doi: 10.1186/s42269-022-00704-4. Epub 2022 Jan 31. PMID: 35125861; PMCID: PMC8802264. 3: Oh KB, Mar W, Kim S, Kim JY, Lee TH, Kim JG, Shin D, Sim CJ, Shin J. Antimicrobial activity and cytotoxicity of bis(indole) alkaloids from the sponge Spongosorites sp. Biol Pharm Bull. 2006 Mar;29(3):570-3. doi: 10.1248/bpb.29.570. PMID: 16508170.

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