SKP-451 is a chemical compound known as 2-pyrrolidinone, 1-((2S)-2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-1-benzopyran-4-yl)-, (S)-. It has the molecular formula C17H18N2O6 and a molecular weight of 346.3346. The compound features a benzopyran structure with a nitro group at position 6, a methyl group at position 2, and a 1,3-dioxolane ring at position 2. SKP-451 is a potassium channel opener, which means it can relax blood vessels and lower blood pressure. Studies have shown that SKP-451 has a higher potency than levcromakalim, another potassium channel opener, in causing vasorelaxation in canine coronary arteries and rabbit basilar and vertebral arteries. Additionally, SKP-451 and its metabolite, SKP-818, produce long-lasting decreases in mean arterial pressure in spontaneously hypertensive rats.
MedKoo Cat#: 145777
Name: SKP-451
CAS#: 181137-41-7
Chemical Formula: C17H18N2O6
Exact Mass: 346.1200
Molecular Weight: 346.34
Elemental Analysis: C, 58.96; H, 5.24; N, 8.09; O, 27.72
The following data is based on the product molecular weight 346.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
