QHL-1 | IRAP inhibitor

MedKoo Cat#: 128427 | Name: QHL-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

QHL-1 is a potent IRAP inhibitor (IC50 = 320 nM).

Chemical Structure

QHL-1

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128427

Name: QHL-1

CAS#: N/A

Chemical Formula: C17H18N2O4S

Exact Mass: 346.0987

Molecular Weight: 346.40

Elemental Analysis: C, 58.95; H, 5.24; N, 8.09; O, 18.47; S, 9.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

QHL-1; QHL 1; QHL1

IUPAC/Chemical Name

2-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-N-hydroxyacetamide

InChi Key

IOHLYYFAABEJOI-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H18N2O4S/c20-17(18-21)11-14-6-3-4-8-16(14)24(22,23)19-10-9-13-5-1-2-7-15(13)12-19/h1-8,21H,9-12H2,(H,18,20)

SMILES Code

O=S(C1=C(CC(NO)=O)C=CC=C1)(N2CCC(C=CC=C3)=C3C2)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 346.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhu D, Liu J, Han R, Shen G, Long Q, Wei X, Liu D. Identification and characterization of ectoine biosynthesis genes and heterologous expression of the ectABC gene cluster from Halomonas sp. QHL1, a moderately halophilic bacterium isolated from Qinghai Lake. J Microbiol. 2014 Feb;52(2):139-47. doi: 10.1007/s12275-014-3389-5. Epub 2014 Feb 1. PMID: 24500478. 2: Gising J, Honarnejad S, Bras M, Baillie GL, McElroy SP, Jones PS, Morrison A, Beveridge J, Hallberg M, Larhed M. The Discovery of New Inhibitors of Insulin- Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds. Int J Mol Sci. 2024 Apr 6;25(7):4084. doi: 10.3390/ijms25074084. PMID: 38612894; PMCID: PMC11012289.