HFI-419 | IRAP inhibitor

MedKoo Cat#: 128426 | Name: HFI-419

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HFI-419is a potent IRAP inhibitor (Ki = 8 0.48 uM).

Chemical Structure

HFI-419

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128426

Name: HFI-419

CAS#: N/A

Chemical Formula: C19H17N2O5

Exact Mass: 353.1137

Molecular Weight: 353.35

Elemental Analysis: C, 64.58; H, 4.85; N, 7.93; O, 22.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HFI-419; HFI 419; HFI419

IUPAC/Chemical Name

ethyl 2-acetamido-7-hydroxy-4-(pyridin-3-yl)-1l3-chromene-3-carboxylate

InChi Key

AXJCRIZWDWLWHZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H17N2O5/c1-3-25-19(24)17-16(12-5-4-8-20-10-12)14-7-6-13(23)9-15(14)26-18(17)21-11(2)22/h4-10,23H,3H2,1-2H3,(H,21,22)

SMILES Code

O=C(OCC)C1=C(C(C=CC(O)=C2)=C2O=C1NC(C)=O)C3=CC=CN=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 353.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mpakali A, Barla I, Lu L, Ramesh KM, Thomaidis N, Stern LJ, Giastas P, Stratikos E. Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J Mol Biol. 2024 Mar 15;436(6):168449. doi: 10.1016/j.jmb.2024.168449. Epub 2024 Jan 18. PMID: 38244767. 2: Krskova K, Balazova L, Dobrocsyova V, Olszanecki R, Suski M, Chai SY, Zorad Š. Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats. Front Mol Biosci. 2020 Dec 4;7:586225. doi: 10.3389/fmolb.2020.586225. PMID: 33344504; PMCID: PMC7746680. 3: Seyer B, Diwakarla S, Burns P, Hallberg A, Grӧnbladh A, Hallberg M, Chai SY. Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake. J Neurochem. 2020 May;153(4):485-494. doi: 10.1111/jnc.14880. Epub 2019 Oct 16. PMID: 31556456. 4: Albiston AL, Cacador M, Sinnayah P, Burns P, Chai SY. Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats. J Mol Endocrinol. 2017 May;58(4):193-198. doi: 10.1530/JME-17-0033. Epub 2017 Mar 29. PMID: 28356324. 5: Wilson RE, Jaquins-Gerstl A, Chen J, Rerick M, Weber SG. Electroosmotic Perfusion-Microdialysis Probe Created by Direct Laser Writing for Quantitative Assessment of Leucine Enkephalin Hydrolysis by Insulin-Regulated Aminopeptidase in Vivo. Anal Chem. 2020 Nov 3;92(21):14558-14567. doi: 10.1021/acs.analchem.0c02799. Epub 2020 Oct 12. PMID: 32961052; PMCID: PMC11027065.