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MedKoo Cat#: 333120 | Name: Boscalid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Boscalid is a broad spectrum fungicide used in agriculture to protect crops from fungal diseases. Its bioactivity profile primarily involves inhibition of fungal respiration by targeting mitochondrial succinate dehydrogenase (Complex II) in the electron transport chain.Boscalid binds to the succinate dehydrogenase enzyme, preventing electron transfer in mitochondrial respiration. This disrupts ATP synthesis and energy production in fungal cells, leading to their death. Boscalid is effective against a wide range of fungal pathogens, including Botrytis, Alternaria, Sclerotinia, and powdery mildew species.

Chemical Structure

Boscalid
Boscalid
CAS#188425-85-6

Theoretical Analysis

MedKoo Cat#: 333120

Name: Boscalid

CAS#: 188425-85-6

Chemical Formula: C18H12Cl2N2O

Exact Mass: 342.0327

Molecular Weight: 343.21

Elemental Analysis: C, 62.99; H, 3.52; Cl, 20.66; N, 8.16; O, 4.66

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
1g USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
Boscalid;
IUPAC/Chemical Name
2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)pyridine-3-carboxamide
InChi Key
WYEMLYFITZORAB-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H12Cl2N2O/c19-13-9-7-12(8-10-13)14-4-1-2-6-16(14)22-18(23)15-5-3-11-21-17(15)20/h1-11H,(H,22,23)
SMILES Code
O=C(C1=CC=CN=C1Cl)NC2=CC=CC=C2C3=CC=C(Cl)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 343.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bui TH, Zuverza-Mena N, Kendrick E, Tamez C, Yadav M, Alotaibi S, Dimkpa C, DeLoid G, Sadik O, Demokritou P, White JC. Micro-nanoscale polystyrene co- exposure impacts the uptake and translocation of arsenic and boscalid by lettuce (Lactuca sativa). NanoImpact. 2025 Jan 8;37:100541. doi: 10.1016/j.impact.2025.100541. Epub ahead of print. PMID: 39793759. 2: Vandensande Y, Carbone M, Mathieu B, Gallez B. Mitochondrial dysfunction induced in human hepatic HepG2 cells exposed to the fungicide kresoxim-methyl and to a mixture kresoxim-methyl/boscalid. Redox Rep. 2024 Dec;29(1):2424677. doi: 10.1080/13510002.2024.2424677. Epub 2024 Nov 14. PMID: 39541499; PMCID: PMC11565682. 3: Hu J, Zhang H, Kong Y, Lamour K, Jung G, Yang Z. Varied sensitivity to boscalid among different Clarireedia species causing dollar spot in turfgrass. Pestic Biochem Physiol. 2024 Sep;204:106029. doi: 10.1016/j.pestbp.2024.106029. Epub 2024 Jul 18. PMID: 39277357. 4: Lin S, Fan H. The occurrence and mechanism of field resistance to boscalid and pyraclostrobin in Stemphylium solani, the causal agent of tomato gray leaf spot in China. Pestic Biochem Physiol. 2024 Sep;204:106028. doi: 10.1016/j.pestbp.2024.106028. Epub 2024 Jul 14. PMID: 39277356. 5: Han S, Sun W, Sun X, Yue Y, Miao J, Dang X, Diao J, Teng M, Zhu W. Co- exposure to boscalid and amoxicillin inhibited the degradation of boscalid and aggravated the threat to the earthworm. Pestic Biochem Physiol. 2024 Aug;203:106022. doi: 10.1016/j.pestbp.2024.106022. Epub 2024 Jul 14. PMID: 39084781. 6: Moschopoulou G, Tsekouras V, Mercader JV, Abad-Fuentes A, Kintzios S. Development of a Portable Cell-Based Biosensor for the Ultra-Rapid Screening for Boscalid Residues in Lettuce. Biosensors (Basel). 2024 Jun 18;14(6):311. doi: 10.3390/bios14060311. PMID: 38920615; PMCID: PMC11201857. 7: Seress D, Molnár O, Matolcsi F, Pintye A, Kovács GM, Németh MZ. Development and Implementation of a Novel CAPS Assay Reveals High Prevalence of a Boscalid Resistance Marker and Its Co-Occurrence with an Azole Resistance Marker in Erysiphe necator. Plant Dis. 2024 Sep;108(9):2607-2614. doi: 10.1094/PDIS-06-23-1114-SR. Epub 2024 Aug 13. PMID: 38616393. 8: Song J, Qiu H, Meng X, Li S, Mao Y, Zhang L, Cai Y, Wang J, Zhou M, Duan Y. Risk assessment and molecular mechanism of Sclerotium rolfsii resistance to boscalid. Pestic Biochem Physiol. 2024 Mar;200:105806. doi: 10.1016/j.pestbp.2024.105806. Epub 2024 Feb 1. PMID: 38582572. 9: Martinović-Weigelt D, Dang MA, Mord A, Goblirsch MJ. Assessment of Mitochondrial Function in the AmE-711 Honey Bee Cell Line: Boscalid and Pyraclostrobin Effects. Environ Toxicol Chem. 2024 May;43(5):976-987. doi: 10.1002/etc.5847. Epub 2024 Mar 15. PMID: 38488751. 10: Bedrossiantz J, Goyenechea J, Prats E, Gómez-Canela C, Barata C, Raldúa D, Cachot J. Cardiac and neurobehavioral impairments in three phylogenetically distant aquatic model organisms exposed to environmentally relevant concentrations of boscalid. Environ Pollut. 2024 Apr 15;347:123685. doi: 10.1016/j.envpol.2024.123685. Epub 2024 Mar 7. PMID: 38460591. 11: Yuan S, Yang J, Fu X, Yu H, Guo Y, Xie Y, Xiao Y, Cheng Y, Yao W. Effect of tannic acid binding on the thermal degradation behavior and product toxicity of boscalid. Food Chem. 2024 Jun 30;444:138654. doi: 10.1016/j.foodchem.2024.138654. Epub 2024 Feb 6. PMID: 38335685. 12: Zhou L, Liu Y, Kong F, Jia S, Wang Q, Wang Z, Zhang H, Huang X. Sensitivity of Botrytis cinerea from Vineyards to Boscalid, Isofetamid, and Pydiflumetofen in Shandong Province, China. Phytopathology. 2024 May;114(5):1068-1074. doi: 10.1094/PHYTO-10-23-0369-KC. Epub 2024 Apr 17. PMID: 38105240. 13: Yue MY, Wang R, Liu YM, Chen BW, Ding WL, Li Y. Resistance of the Ginseng Gray Mold Pathogen, Botrytis cinerea, to Boscalid and Pyraclostrobin Fungicides in China. Plant Dis. 2024 Apr;108(4):979-986. doi: 10.1094/PDIS-02-23-0321-RE. Epub 2024 Apr 19. PMID: 38012822. 14: Carbone M, Mathieu B, Vandensande Y, Gallez B. Impact of Exposure to Pyraclostrobin and to a Pyraclostrobin/Boscalid Mixture on the Mitochondrial Function of Human Hepatocytes. Molecules. 2023 Oct 10;28(20):7013. doi: 10.3390/molecules28207013. PMID: 37894492; PMCID: PMC10609024. 15: Zhou R, Sun B, Zhu G, Xie X, Chai A, Li L, Fan T, Li B, Shi Y. Monitoring Corynespora cassiicola Resistance to Boscalid, Trifloxystrobin, and Carbendazim in China. Phytopathology. 2024 Feb;114(2):359-367. doi: 10.1094/PHYTO-06-23-0186-R. Epub 2024 Feb 19. PMID: 37665395. 16: Achilonu CC, Gryzenhout M, Ghosh S, Marais GJ. In Vitro Evaluation of Azoxystrobin, Boscalid, Fentin-Hydroxide, Propiconazole, Pyraclostrobin Fungicides against Alternaria alternata Pathogen Isolated from Carya illinoinensis in South Africa. Microorganisms. 2023 Jun 29;11(7):1691. doi: 10.3390/microorganisms11071691. PMID: 37512864; PMCID: PMC10384428. 17: Schuhmann A, Scheiner R. A combination of the frequent fungicides boscalid and dimoxystrobin with the neonicotinoid acetamiprid in field-realistic concentrations does not affect sucrose responsiveness and learning behavior of honeybees. Ecotoxicol Environ Saf. 2023 May;256:114850. doi: 10.1016/j.ecoenv.2023.114850. Epub 2023 Apr 3. PMID: 37018858. 18: Dong J, Huang M, Guo H, Zhang J, Tan X, Wang D. Ternary Mixture of Azoxystrobin, Boscalid and Pyraclostrobin Disrupts the Gut Microbiota and Metabolic Balance of Honeybees (Apis cerana cerana). Int J Mol Sci. 2023 Mar 10;24(6):5354. doi: 10.3390/ijms24065354. PMID: 36982426; PMCID: PMC10049333. 19: Bhatt D, Srivastava A, Srivastava PC. An insight into the sorption kinetics of boscalid onto soils: Effect of general soil properties. Chemosphere. 2023 Jun;325:138274. doi: 10.1016/j.chemosphere.2023.138274. Epub 2023 Mar 4. PMID: 36878363. 20: Fu X, Yuan S, Yang F, Yu H, Xie Y, Guo Y, Yao W. Characterization of the interaction between boscalid and tannic acid and its effect on the antioxidant properties of tannic acid. J Food Sci. 2023 Apr;88(4):1325-1335. doi: 10.1111/1750-3841.16488. Epub 2023 Feb 14. PMID: 36786363.