Synonym
U-104067; U104067; U 104067;
IUPAC/Chemical Name
4-(2-(2,4-di(pyrrolidin-1-yl)-9H-pyrimido[4,5-b]indol-9-yl)ethyl)morpholine
InChi Key
OSWIGURBWHFXSX-UHFFFAOYSA-N
InChi Code
1S/C24H32N6O/c1-2-8-20-19(7-1)21-22(28-9-3-4-10-28)25-24(29-11-5-6-12-29)26-23(21)30(20)14-13-27-15-17-31-18-16-27/h1-2,7-8H,3-6,9-18H2
SMILES Code
C(CN1CCOCC1)N2C3=NC(=NC(N4CCCC4)=C3C5=C2C=CC=C5)N6CCCC6
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
420.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Epps DE, Wilson CL, Vosters AF, Kézdy FJ. The pretransition of dipalmitoyllecithin bilayers as probed by the fluorescent pyrrolopyrimidine, U-104067. Chem Phys Lipids. 1997 Apr 25;86(2):121-33. doi: 10.1016/s0009-3084(97)02661-3. PMID: 9179994.
2: Sethy VH, Wu H, Oostveen JA, Hall ED. Neuroprotective effects of the pyrrolopyrimidine U-104067F in 3-acetylpyridine-treated rats. Exp Neurol. 1996 Jul;140(1):79-83. doi: 10.1006/exnr.1996.0117. PMID: 8682182.
3: Andrus PK, Fleck TJ, Oostveen JA, Hall ED. Neuroprotective effects of the novel brain-penetrating pyrrolopyrimidine antioxidants U-101033E and U-104067F against post-ischemic degeneration of nigrostriatal neurons. J Neurosci Res. 1997 Mar 15;47(6):650-4. doi: 10.1002/(sici)1097-4547(19970315)47:6<650::aid- jnr11>3.0.co;2-z. PMID: 9089214.
4: Smith SL, Oostveen JA, Hall ED. Two novel pyrrolopyrimidine lipid peroxidation inhibitors U-101033E and U-104067F protect facial motor neurons following neonatal axotomy. Exp Neurol. 1996 Oct;141(2):304-9. doi: 10.1006/exnr.1996.0165. PMID: 8812165.
5: Bundy GL, Ayer DE, Banitt LS, Belonga KL, Mizsak SA, Palmer JR, Tustin JM, Chin JE, Hall ED, Linseman KL, et al. Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J Med Chem. 1995 Oct 13;38(21):4161-3. doi: 10.1021/jm00021a004. PMID: 7473542.
