BRD-4592 is a small-molecule, allosteric inhibitor targeting Mycobacterium tuberculosis tryptophan synthase (TrpAB). It binds at the α-β-subunit interface of TrpAB, exhibiting inhibitory concentrations (IC50) of 70.9 nM for the α-subunit and 22.6 nM for the β-subunit. This compound has demonstrated high efficacy in vivo. BRD-4592 is primarily utilized in research settings to study the inhibition of tryptophan biosynthesis in M. tuberculosis, which is essential for the bacterium's survival and pathogenicity. By targeting this pathway, BRD-4592 holds potential as a lead compound for developing new anti-tuberculosis therapies.
MedKoo Cat#: 145767
Name: BRD-4592
CAS#: 2119598-24-0
Chemical Formula: C17H15FN2O
Exact Mass: 282.1200
Molecular Weight: 282.32
Elemental Analysis: C, 72.33; H, 5.36; F, 6.73; N, 9.92; O, 5.67
The following data is based on the product molecular weight 282.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
