MedKoo Cat#: 145760 | Name: LPT-99

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LPT-99 is a selective inhibitor of the protein enzyme phosphodiesterase 4 (PDE4). PDE4 plays a role in the breakdown of cyclic AMP (cAMP), a molecule involved in various signaling pathways within cells. By inhibiting PDE4, LPT-99 increases cAMP levels, which can lead to anti-inflammatory effects. It has been investigated for potential therapeutic applications in conditions where inflammation is a key factor, such as chronic obstructive pulmonary disease (COPD), asthma, and other inflammatory disorders.

Chemical Structure

LPT-99
LPT-99
CAS#1263477-83-3

Theoretical Analysis

MedKoo Cat#: 145760

Name: LPT-99

CAS#: 1263477-83-3

Chemical Formula: C31H32Cl2N4O4S

Exact Mass: 626.1500

Molecular Weight: 627.58

Elemental Analysis: C, 59.33; H, 5.14; Cl, 11.30; N, 8.93; O, 10.20; S, 5.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
LPT-99; LPT 99; LPT99;
IUPAC/Chemical Name
2-(4-(2,4-dichlorophenethyl)-3,6-dioxo-1-(2-(thiophen-2-yl)ethyl)piperazin-2-yl)-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)acetamide
InChi Key
XLXXBYJYWULGGD-UHFFFAOYSA-N
InChi Code
1S/C31H32Cl2N4O4S/c1-41-23-6-7-27-25(16-23)21(18-35-27)8-11-34-29(38)17-28-31(40)36(12-9-20-4-5-22(32)15-26(20)33)19-30(39)37(28)13-10-24-3-2-14-42-24/h2-7,14-16,18,28,35H,8-13,17,19H2,1H3,(H,34,38)
SMILES Code
COC1=CC2=C(NC=C2CCNC(=O)CC3N(CCC4=CC=CS4)C(=O)CN(CCC5=CC=C(Cl)C=C5Cl)C3=O)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 627.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Murillo-Cuesta S, Celaya AM, Cervantes B, Bermúdez-Muñoz JM, Rodríguez-de la Rosa L, Contreras J, Sánchez-Pérez I, Varela-Nieto I. Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss. Clin Transl Med. 2021 Apr;11(4):e363. doi: 10.1002/ctm2.363. PMID: 33931965; PMCID: PMC8021538.