IUPAC/Chemical Name
(R)-1'-(4-iodobenzyl)-3-phenyl-[3,4'-bipiperidine]-2,6-dione
InChi Key
WJLRTFJPHDSXAF-QHCPKHFHSA-N
InChi Code
1S/C23H25IN2O2/c24-20-8-6-17(7-9-20)16-26-14-11-19(12-15-26)23(18-4-2-1-3-5-18)13-10-21(27)25-22(23)28/h1-9,19H,10-16H2,(H,25,27,28)/t23-/m0/s1
SMILES Code
IC1=CC=C(CN2CCC(CC2)[C@]3(CCC(=O)NC3=O)C4=CC=CC=C4)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
488.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Müller-Gärtner HW, Wilson AA, Dannals RF, Wagner HN Jr, Frost JJ. Imaging muscarinic cholinergic receptors in human brain in vivo with Spect, [123I]4-iododexetimide, and [123I]4-iodolevetimide. J Cereb Blood Flow Metab. 1992 Jul;12(4):562-70. doi: 10.1038/jcbfm.1992.80. PMID: 1618935.
2: Sasaki M, Müller-Gärtner HW, Lever JR, Ravert HT, Dannals RF, Guilarte TR, Wagner HN Jr. Assessment of brain muscarinic acetylcholinergic receptors in living mice using a simple probe, [125I]-4-iododexetimide and [125I]-4-iodolevetimide. Neuropharmacology. 1993 Dec;32(12):1441-3. doi: 10.1016/0028-3908(93)90043-3. PMID: 8152535.
3: Kassiou M, Mardon K, Katsifis AG, Najdovski L, Dikic B, Mattner F, Lambrecht RM, Hicks RJ, Eu P, Loc'h C. Radiosynthesis of [123I]N-methyl-4-iododexetimide and [123I]N-methyl-4-iodolevetimide: in vitro and in vivo characterisation of binding to muscarinic receptors in the rat heart. Nucl Med Biol. 1996 Feb;23(2):147-53. doi: 10.1016/0969-8051(95)02045-4. PMID: 8868287.
4: Matsumura K, Uno Y, Scheffel U, Wilson AA, Dannals RF, Wagner HN Jr. In vitro and in vivo characterization of 4-[125I]iododexetimide binding to muscarinic cholinergic receptors in the rat heart. J Nucl Med. 1991 Jan;32(1):76-80. PMID: 1988640.
5: Hicks RJ, Kassiou M, Eu P, Katsifis AG, Garra M, Power J, Najdovski L, Lambrecht RM. Iodine-123 N-methyl-4-iododexetimide: a new radioligand for single-photon emission tomographic imaging of myocardial muscarinic receptors. Eur J Nucl Med. 1995 Apr;22(4):339-45. doi: 10.1007/BF00941851. PMID: 7607265.
