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MedKoo Cat#: 145739 | Name: Indralin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indralin is an investigational small molecule. This compound has been studied for its potential as a radioprotective agent, designed to prevent acute radiation damage during high-dose ionizing radiation exposure. Research indicates that Indralin may reduce the risk of mortality from severe acute radiation illness by up to 1.5 times.

Chemical Structure

Indralin
Indralin
CAS#156691-86-0

Theoretical Analysis

MedKoo Cat#: 145739

Name: Indralin

CAS#: 156691-86-0

Chemical Formula: C23H28O2S

Exact Mass: 368.1800

Molecular Weight: 368.54

Elemental Analysis: C, 74.96; H, 7.66; O, 8.68; S, 8.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Indralin; Indraline; AGN-191659; AGN191659; AGN 191659;
IUPAC/Chemical Name
(E)-5-(2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)thiophene-2-carboxylic acid
InChi Key
QPAMXNZWXFZISY-SDNWHVSQSA-N
InChi Code
1S/C23H28O2S/c1-14(11-16-7-8-20(26-16)21(24)25)17-13-19-18(12-15(17)2)22(3,4)9-10-23(19,5)6/h7-8,11-13H,9-10H2,1-6H3,(H,24,25)/b14-11+
SMILES Code
C\C(=C/C1=CC=C(S1)C(O)=O)C2=CC3=C(C=C2C)C(C)(C)CCC3(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vasin MM, Ushakov IB, Kovtun VY. Radioprotector indralin at early and late manifestations of local radiation injuries. Vopr Onkol. 2016;62(3):406-12. PMID: 30462902. 2: Romodin LA, Nikitenko OV, Bychkova TM, Zrilova YA, Rodionova ED, Bocharov DA. Radioprotective Properties of Riboxin (Inosine) and Indralin under External Irradiation. Bull Exp Biol Med. 2024 Mar;176(5):572-575. doi: 10.1007/s10517-024-06069-0. Epub 2024 May 10. PMID: 38730104. 3: Vasin MV, Semenov LF, Suvorov NN, Antipov VV, Ushakov IB, Ilyin LA, Lapin BA. Protective effect and the therapeutic index of indralin in juvenile rhesus monkeys. J Radiat Res. 2014 Nov;55(6):1048-55. doi: 10.1093/jrr/rru046. Epub 2014 Jul 10. PMID: 25012697; PMCID: PMC4229912. 4: Romodin LA, Nikitenko OV, Bychkova TM, Zrilova YA, Rodionova ED, Bocharov DA. Comparative Evaluation of the Radioprotective Properties of Copper Chlorophyllin, Trolox, and Indralin in an Experiment on Mice. Bull Exp Biol Med. 2024 Jul;177(3):328-332. doi: 10.1007/s10517-024-06183-z. Epub 2024 Aug 10. PMID: 39126544. 5: Vasin MV, Ushakov IB, Kovtun VY, Komarova SN, Semenova LA, Galkin AA, Afanas'ev RV, Bukhtiyarov IV. Pharmacological Analysis of the Therapeutic Effect of Radioprotectors Cystamine and Indralin in the Capacity of Radiomitigators. Bull Exp Biol Med. 2017 Feb;162(4):466-469. doi: 10.1007/s10517-017-3641-1. Epub 2017 Feb 27. PMID: 28239785. 6: Vasin MV, Gan'shina TS, Mirzoyan RS, Semenova LA, Koroleva LV, Afanas'ev RV, Ushakov IB. Mitigating Effect of Nitrates (Monizol) on Pharmacodynamic Shifts in the Cardiovascular System Caused by Radioprotector Indralin. Bull Exp Biol Med. 2018 Jul;165(3):364-367. doi: 10.1007/s10517-018-4171-1. Epub 2018 Jul 13. PMID: 30006873. 7: Vasin MV, Ushakov IB, Kovtun VY, Semenova LA, Komarova SN, Galkin AA, Afanas'ev RV. Radioprotective Properties of Indralin in Combination with Monizol in the Treatment of Local Acute and Delayed Radiation Injuries Caused by Local Skin γ-Irradiation. Bull Exp Biol Med. 2015 Oct;159(6):747-9. doi: 10.1007/s10517-015-3065-8. Epub 2015 Oct 31. PMID: 26519270. 8: Shliakova TG, Sharygin VL, Zorin VV, Chernov GA, Pulatova MK. [Influence of indoinetophene on the antiradiation properties of indralin]. Radiats Biol Radioecol. 2014 Jan-Feb;54(1):50-6. Russian. PMID: 25764845. 9: Vasin MV, Ushakov IB, Kovtun VY, Komarova SN, Semenova LA. Effect of radioprotector indralin on carboplatinum hemotoxicity. Bull Exp Biol Med. 2006 Apr;141(4):437-9. doi: 10.1007/s10517-006-0193-1. PMID: 17152365. 10: Vasin MV, Ushakov IB, Korovkina EP, Kovtun VIu. Effect of α₁-adrenomimetic indralin on oxygen consumption by bone marrow cells in vitro. Bull Exp Biol Med. 2013 Jul;155(3):360-2. doi: 10.1007/s10517-013-2153-x. PMID: 24137603. 11: Chernov GA, Shliakova TG, Sharygin VL, Sharf VG, Todorov IN, Mitrokhin IuI, Efremova OI, Khristianovich DS, Rozantseva TV, Pulatova MK. Molekuliarnye aspekty deĭstviia radioprotektora indralina [The molecular aspects of the action of the radioprotector indralin]. Izv Akad Nauk Ser Biol. 1994 Jan-Feb;(1):20-37. Russian. PMID: 7512850. 12: Vasin MV, Ushakov IB. Comparative efficacy and the window of radioprotection for adrenergic and serotoninergic agents and aminothiols in experiments with small and large animals. J Radiat Res. 2015 Jan;56(1):1-10. doi: 10.1093/jrr/rru087. Epub 2014 Oct 13. PMID: 25312329; PMCID: PMC4572585. 13: Vasin MV, Chernov GA, Antipov VV. Shirota radiozashchitnogo deĭstviia indralina v sravnitelnykh issledovaniiakh na razlichnykh vidakh zhivotnykh [Width of radiation protective effects of indralin in comparative studies using different animal species]. Radiats Biol Radioecol. 1997 Nov-Dec;37(6):896-904. Russian. PMID: 9467644. 14: Vasin MV, Ushakov IB, Antipov VV. Potential Role of Catecholamine Response to Acute Hypoxia in the Modification of the Effects of Radioprotectors. Bull Exp Biol Med. 2015 Sep;159(5):597-600. doi: 10.1007/s10517-015-3022-6. Epub 2015 Oct 13. PMID: 26459484. 15: Vasin MV, Ushakov IB, Kovtun VY, Komarova SN, Semenova LA, Koroleva LV, Galkin AA, Afanas'ev RV. Effect of radioprotector Indralin on the course of acute GVH disease. Bull Exp Biol Med. 2008 Nov;146(5):573-6. doi: 10.1007/s10517-009-0336-2. PMID: 19526094. 16: Shashkov VS, Efimov VI, Vasin MV, Antipov VV, Iliukhin AV, Vlasov PA, Karsanova SK, Grigor'ev IuG, Ushakov IB. [Indralin--a novel effective radioprotector during irradiation by high-energy protons]. Aviakosm Ekolog Med. 2010 Jan-Feb;44(1):15-20. Russian. PMID: 20803992. 17: Vasin MV, Antipov VV, Komarova SN, Semenova LA, Galkin AA. [Radioprotective properties of indralin combined with cystamine and mexamine]. Radiats Biol Radioecol. 2011 Mar-Apr;51(2):243-6. Russian. PMID: 21674951. 18: Davydov BI, Soldatov SK, Zuev VG, Ushakov IB. Zashchitnaia aktivnost' meksamina i indralina pri intensivnom élektromagnitnom obluchenii krys [Protective action of mexamine and indralin in intensive electromagnetic irradiation of rats]. Radiats Biol Radioecol. 1995 Jan-Feb;35(1):74-7. Russian. PMID: 7719436. 19: Vasin MV, Chernov GA, Koroleva LV, L'vova TS, Abramov MM, Antipov VV, Suvorov NN. K mekhanizmu protivoluchevogo deĭstviia indralina [Mechanism of the radiation-protective effect of indralin]. Radiats Biol Radioecol. 1996 Jan- Feb;36(1):36-46. Russian. PMID: 8696483. 20: Deshevoĭ IuB, Moroz BB, Seredenin SB, Lyrshikova AV, Lebedev VG. Farmakologicheskaia korrektsiia émotsional'nogo stressa v usloviiakh vozdeĭstviia na organizm ioniziruiushchego izlucheniia i primeneniia radioprotektora - indralina [Pharmacological correction of emotional stress after exposure to ionizing radiation and treatment with a radioprotector indralin]. Radiats Biol Radioecol. 2003 Jan-Feb;43(1):56-9. Russian. PMID: 12677659.

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