Synonym
AZ14240475; AZ 14240475; AZ-14240475
IUPAC/Chemical Name
1-(2-(5-(3-chlorophenoxy)-2,4-difluorophenyl)-1-(pyrimidin-4-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)prop-2-en-1-one
InChi Key
ZDGSOVZSSXQNMT-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H16ClF2N5O2/c1-2-23(33)31-11-19-20(12-31)32(22-6-7-28-13-29-22)24(30-19)16-9-21(18(27)10-17(16)26)34-15-5-3-4-14(25)8-15/h2-10,13H,1,11-12H2
SMILES Code
C=CC(N(C1)CC2=C1N=C(C3=CC(OC4=CC=CC(Cl)=C4)=C(F)C=C3F)N2C5=NC=NC=C5)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
479.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations
William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Miguel A. Cortés González, Sabina Cosulich, Nichola L. Davies, Nicolas Floc’h, Ryan Greenwood, David Hargreaves, Peng Huang, Thomas A. Hunt, Tony Johnson, Peter Johnström, Jason G. Kettle, Mikhail Kondrashov, Demetrios H. Kostomiris, Songlei Li, Andrew Lister, Scott Martin, Darren McKerrecher, Neville McLean, J. Willem M. Nissink, Jonathan P. Orme, Paige Orwig, Martin J. Packer, Stuart Pearson, Lina Qin, Catarina Felisberto-Rodrigues, Adriana Savoca, Magnus Schou, Stephen Stokes, Aisha M. Swaih, Sara Talbot, Michael J. Tucker, Richard A. Ward, Emma Wadforth, Chunli Wang, Joanne Wilson, and Yawen Yang
Journal of Medicinal Chemistry Article ASAP
DOI: 10.1021/acs.jmedchem.4c02811
