DA-1241 | GPR119 agonist | CAS#1914136-10-9

MedKoo Cat#: 128387 | Name: DA-1241

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DA-1241 is a GPR119 agonist.

Chemical Structure

DA-1241

CAS#1914136-10-9

Theoretical Analysis

MedKoo Cat#: 128387

Name: DA-1241

CAS#: 1914136-10-9

Chemical Formula: C25H31F2N5O2

Exact Mass: 471.2446

Molecular Weight: 471.55

Elemental Analysis: C, 63.68; H, 6.63; F, 8.06; N, 14.85; O, 6.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DA-1241; DA1241; DA 1241

IUPAC/Chemical Name

3-(4-(3-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)propoxy)-2,6-difluorophenyl)-5-isopropyl-1,2,4-oxadiazole

InChi Key

XQSZLXRXPGLHLH-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H31F2N5O2/c1-4-17-14-28-25(29-15-17)32-9-7-18(8-10-32)6-5-11-33-19-12-20(26)22(21(27)13-19)23-30-24(16(2)3)34-31-23/h12-16,18H,4-11H2,1-3H3

SMILES Code

FC1=CC(OCCCC2CCN(C3=NC=C(CC)C=N3)CC2)=CC(F)=C1C4=NOC(C(C)C)=N4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 471.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kim Y, Lee SW, Wang H, Kim RH, Park HK, Lee H, Kang ES. DA-1241, a Novel GPR119 Agonist, Improves Hyperglycaemia by Inhibiting Hepatic Gluconeogenesis and Enhancing Insulin Secretion in Diabetic Mice. Diabetes Metab J. 2022 Mar;46(2):337-348. doi: 10.4093/dmj.2021.0056. Epub 2022 Jan 21. PMID: 35052026; PMCID: PMC8987681. 2: Lee SH, Park H, Yang EK, Lee BR, Jung IH, Kim TH, Goo MJ, Chae Y, Kim MK. GPR119 activation by DA-1241 alleviates hepatic and systemic inflammation in MASH mice through inhibition of NFκB signaling. Biomed Pharmacother. 2023 Oct;166:115345. doi: 10.1016/j.biopha.2023.115345. Epub 2023 Aug 31. PMID: 37657264. 3: Kim MK, Cheong YH, Lee SH, Kim TH, Jung IH, Chae Y, Lee JH, Yang EK, Park H, Yang JS, Hong KW. A novel GPR119 agonist DA-1241 preserves pancreatic function via the suppression of ER stress and increased PDX1 expression. Biomed Pharmacother. 2021 Dec;144:112324. doi: 10.1016/j.biopha.2021.112324. Epub 2021 Oct 19. PMID: 34678732. 4: Al Smadi K, Qureshi A, Ashouri B, Kayali Z. Investigational new drug approval of DA-1241: what we know about GPR119 targeting for MASH therapy? Expert Opin Investig Drugs. 2024 Sep;33(9):877-880. doi: 10.1080/13543784.2024.2388592. Epub 2024 Aug 7. PMID: 39092979. 5: Chen CL, Lin YC. Autophagy Dysregulation in Metabolic Associated Fatty Liver Disease: A New Therapeutic Target. Int J Mol Sci. 2022 Sep 2;23(17):10055. doi: 10.3390/ijms231710055. PMID: 36077452; PMCID: PMC9456355.