BOD-Azo-single is a hypoxia-activated prodrug BOD-Azo-single with a PDT agent and aniline mustard connected by the azo bond. With light illumination, BOD-Azo-single exhibited some PDT. Under hypoxic conditions, the azo bond cleaved and released BOD-3-single of higher phototoxicity and aniline mustard of chemo-toxicity. In vivo therapeutic experiments showed that BOD-Azo-single with light significantly reduced A375 tumor proliferation with 92% TGI value.
MedKoo Cat#: 128361
Name: BOD-Azo-single
CAS#: N/A
Chemical Formula: C43H38BBr2Cl2F2N5O
Exact Mass: 917.0881
Molecular Weight: 920.33
Elemental Analysis: C, 56.12; H, 4.16; B, 1.17; Br, 17.36; Cl, 7.70; F, 4.13; N, 7.61; O, 1.74
The following data is based on the product molecular weight 920.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
