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MedKoo Cat#: 145678 | Name: Dehydromiltirone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dehydromiltirone is the active component of Salvia miltiorrhiza. Dehydromiltirone has therapeutic effects on SI-AKI, sepsis-induced AKI.

Chemical Structure

Dehydromiltirone
Dehydromiltirone
CAS#116064-77-8

Theoretical Analysis

MedKoo Cat#: 145678

Name: Dehydromiltirone

CAS#: 116064-77-8

Chemical Formula: C19H20O2

Exact Mass: 280.1500

Molecular Weight: 280.37

Elemental Analysis: C, 81.40; H, 7.19; O, 11.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dehydromiltirone;
IUPAC/Chemical Name
2-isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4-dione
InChi Key
FQRLDPKLRMEKLQ-UHFFFAOYSA-N
InChi Code
1S/C19H20O2/c1-11(2)14-10-12-7-8-15-13(6-5-9-19(15,3)4)16(12)18(21)17(14)20/h5-8,10-11H,9H2,1-4H3
SMILES Code
CC(C)C1=CC2=C(C(=O)C1=O)C3=C(C=C2)C(C)(C)CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 280.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Deng W, Huang Y, Li H, Chen C, Lin Y, Wang M, Huang H, Liu T, Qin Q, Shao Y, Tang Y, Yuan K, Ding J, Xu L, Li Y, Zhang S. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693. doi: 10.3389/fphar.2022.1015693. PMID: 36210855; PMCID: PMC9533194. 2: Wang Y, Liu Y, Chen S, Li F, Wu Y, Xie X, Zhang N, Zeng C, Bai L, Dai M, Zhang L, Wang X. The protective mechanism of Dehydromiltirone in diabetic kidney disease is revealed through network pharmacology and experimental validation. Front Pharmacol. 2023 Aug 23;14:1201296. doi: 10.3389/fphar.2023.1201296. PMID: 37680723; PMCID: PMC10482231. 3: Chen S, Wang Y, Liu Y, Bai L, Li F, Wu Y, Xie X, Zhang N, Zeng C, Zhang L, Wang X. Investigating the effect of dehydromiltirone on septic AKI using a network pharmacology method, molecular docking, and experimental validation. Front Pharmacol. 2023 Mar 15;14:1145675. doi: 10.3389/fphar.2023.1145675. PMID: 37007048; PMCID: PMC10050741. 4: Lin LZ, Wang XM, Huang XL, Huang Y, Yang BJ. [A new diterpenoid quinone dehydromiltirone]. Yao Xue Xue Bao. 1988 Apr;23(4):273-5. Chinese. PMID: 3176980. 5: Pei M, Xu D, Wu L. Editorial: Bone and Cartilage Diseases - The Role and Potential of Natural Products, Volume II. Front Pharmacol. 2023 May 2;14:1194875. doi: 10.3389/fphar.2023.1194875. PMID: 37201019; PMCID: PMC10185899. 6: Yue S, Hu B, Wang Z, Yue Z, Wang F, Zhao Y, Yang Z, Shen M. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52(10):1278-85. doi: 10.3109/13880209.2014.889720. Epub 2014 Jul 15. PMID: 25026357. 7: Yang LX, Li XC, Liu C, Xiao L, Qin DH, Chen RY. [Chemical constituents from Salvia przewalskii Maxim]. Yao Xue Xue Bao. 2011 Jul;46(7):818-21. Chinese. PMID: 22010351. 8: Sun C, Cui L, Zhou B, Wang X, Guo L, Liu W. Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI. J Pharm Anal. 2022 Oct;12(5):719-724. doi: 10.1016/j.jpha.2021.09.011. Epub 2021 Sep 20. PMID: 36320597; PMCID: PMC9615513. 9: Bai YL, Cui XY, Yuan YY, Zhang YT, Wang W, Liu TH, Wu Y. [Mechanism of Shexiang Tongxin Dropping Pills in treating diabetic cardiomyopathy based on network pharmacology and animal experiments]. Zhongguo Zhong Yao Za Zhi. 2024 Apr;49(7):1905-1914. Chinese. doi: 10.19540/j.cnki.cjcmm.20231127.401. PMID: 38812203. 10: Luo HW, Hu XJ, Wang N, Ji J. [Platelet aggregation inhibitors from Salvia miltiorrhiza Bunge]. Yao Xue Xue Bao. 1988 Nov;23(11):830-4. Chinese. PMID: 3257038.