MedKoo Cat#: 128338 | Name: PI3K/AKT-IN-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor (IC50 of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively).

Chemical Structure

PI3K/AKT-IN-1
PI3K/AKT-IN-1
CAS#3033069-84-7

Theoretical Analysis

MedKoo Cat#: 128338

Name: PI3K/AKT-IN-1

CAS#: 3033069-84-7

Chemical Formula: C23H23N5O4S

Exact Mass: 465.1471

Molecular Weight: 465.53

Elemental Analysis: C, 59.34; H, 4.98; N, 15.04; O, 13.75; S, 6.89

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
PI3K/AKT-IN-1; PI3K/AKT IN 1; PI3K/AKT-IN 1; PI3K/AKTIN1
IUPAC/Chemical Name
(E)-4-(4-methoxyphenyl)-2-(methylthio)-6-(2-(3,4,5-trimethoxybenzylidene)hydrazineyl)pyrimidine-5-carbonitrile
InChi Key
WGUUTVSZGSTNKU-DHRITJCHSA-N
InChi Code
InChI=1S/C23H23N5O4S/c1-29-16-8-6-15(7-9-16)20-17(12-24)22(27-23(26-20)33-5)28-25-13-14-10-18(30-2)21(32-4)19(11-14)31-3/h6-11,13H,1-5H3,(H,26,27,28)/b25-13+
SMILES Code
N#CC1=C(N/N=C/C2=CC(OC)=C(OC)C(OC)=C2)N=C(SC)N=C1C3=CC=C(OC)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 465.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
El-Dydamony NM, Abdelnaby RM, Abdelhady R, Ali O, Fahmy MI, R Fakhr Eldeen R, Helwa AA. Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562. J Enzyme Inhib Med Chem. 2022 Dec;37(1):895-911. doi: 10.1080/14756366.2022.2051022. PMID: 35345960; PMCID: PMC8967206.