Synonym
Bemethyl; Bemactor; Bemithyl; Bemitil; NP 135
IUPAC/Chemical Name
2-(ethylthio)-1H-benzo[d]imidazole
InChi Key
UGCOPUIBNABIEP-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H10N2S/c1-2-12-9-10-7-5-3-4-6-8(7)11-9/h3-6H,2H2,1H3,(H,10,11)
SMILES Code
CCSC1=NC2=C(C=CC=C2)N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
178.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Todorova V, Ivanov K, Delattre C, Nalbantova V, Karcheva-Bahchevanska D,
Ivanova S. Plant Adaptogens-History and Future Perspectives. Nutrients. 2021 Aug
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2: Belinskaia DA, Savelieva EI, Karakashev GV, Orlova OI, Leninskii MA,
Khlebnikova NS, Shestakova NN, Kiskina AR. Investigation of Bemethyl
Biotransformation Pathways by Combination of LC-MS/HRMS and In Silico Methods.
Int J Mol Sci. 2021 Aug 21;22(16):9021. doi: 10.3390/ijms22169021. PMID:
34445727; PMCID: PMC8396642.
3: Gaĭvoronskaia VV, Okovityĭ SV, Shustov EB, Smirnov AV. Vliianie bemitila,
étomerzola i iaktona na protsessy regeneratsii pecheni posle chastichnoĭ
gepatoéktomii [Effects of bemethyl, ethomersol, and yakton on the liver
regeneration after partial hepatectomy]. Eksp Klin Farmakol. 2000 Sep-
Oct;63(5):34-6. Russian. PMID: 11109523.
4: Bobkov IuG, Machula AI, Morozov IuI, Dvalishvili EG. Analiz struktury
funktsional'nogo sostoianiia mozga pri deĭstvii bemitila metodami teorii
raspoznavaniia obrazov [Structural analysis of the functional status of the
brain as affected by bemethyl using pattern recognition theory]. Biull Eksp Biol
Med. 1987 Nov;104(11):574-6. Russian. PMID: 3676492.
5: Zarubina IV, Mironova OP. Vliianie bemitila na glutationovuiu sistemu v
pecheni krys pri ostroĭ gipoksii [Effect of bemethyl on the glutathione system
in the rat liver in acute hypoxia]. Eksp Klin Farmakol. 2002 May-
Jun;65(3):28-30. Russian. PMID: 12227091.
6: Novikov VS. Effektivnost' profilakticheskogo primeneniia bemitina v
usloviiakh dlitel'nogo plavaniia [Efficiency of preventive use of bemethyl
during long-term voyages]. Gig Sanit. 1991 Mar;(3):37-9. Russian. PMID: 1885014.
7: Sorokina EA, Sibiriak SV, Sergeeva SA. Vliianie bemitila na tsitokhrom
P-450-zavisimye monoksigenazy v pecheni krys i limfotsitakh cheloveka [Effect of
bemethyl on cytochrome P-450-dependent monoxygenases in the human liver and
lymphocytes]. Eksp Klin Farmakol. 2002 May-Jun;65(3):31-4. Russian. PMID:
12227093.
8: Kudriavtseva MV, Bezborodkina NN, Okovityĭ SV, Ivanova OV, Kudriavtsev BN.
Osobennosti vliianiia bemitila na metabolizm glikogena v gepatotsitakh
patologicheski izmenennoĭ pecheni cheloveka [Features of the effect of bemethyl
on glycogen metabolism in hepatocytes of pathological changed human liver].
Tsitologiia. 2002;44(7):668-75. Russian. PMID: 12455377.
9: Vislobokov AI, Marysheva VV, Shabanov PD. Membrannye mekhanizmy deĭstviia
antigipoksantov bemitila i almida na neĭrony molliuskov [Membrane mechanisms of
effects of antihypoxic agents bemethyl and almide on neurons of Mollusca]. Eksp
Klin Farmakol. 2003 Nov-Dec;66(6):9-11. Russian. PMID: 14743702.
10: Baulin SI, Rogacheva SM, Afanaseva SV, Zabanova EV, Karagaycheva YV.
Pharmaceutical Composition for Improving Physical Working Capacity. Bull Exp
Biol Med. 2015 Nov;160(1):45-8. doi: 10.1007/s10517-015-3094-3. Epub 2015 Nov
25. PMID: 26601841.
