Oroxin B (OB) | flavonoid | CAS#114482-86-9

MedKoo Cat#: 128322 | Name: Oroxin B

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent.

Chemical Structure

Oroxin B

CAS#114482-86-9

Theoretical Analysis

MedKoo Cat#: 128322

Name: Oroxin B

CAS#: 114482-86-9

Chemical Formula: C27H30O15

Exact Mass: 594.1585

Molecular Weight: 594.52

Elemental Analysis: C, 54.55; H, 5.09; O, 40.37

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 550.00	2 Weeks
25mg	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Oroxin B; Oroxin-B; OroxinB; Baicalin-7-O-diglucoside

IUPAC/Chemical Name

5,6-dihydroxy-2-phenyl-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

InChi Key

HAYLVXFWJCKKDW-IJTBWITGSA-N

InChi Code

InChI=1S/C27H30O15/c28-8-15-19(31)22(34)24(36)26(41-15)38-9-16-20(32)23(35)25(37)27(42-16)40-14-7-13-17(21(33)18(14)30)11(29)6-12(39-13)10-4-2-1-3-5-10/h1-7,15-16,19-20,22-28,30-37H,8-9H2/t15-,16-,19-,20-,22+,23+,24-,25-,26-,27-/m1/s1

SMILES Code

OC1=C2C(OC(C3=CC=CC=C3)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=C1O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 594.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W. Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy. Front Endocrinol (Lausanne). 2022 Dec 1;13:1060721. doi: 10.3389/fendo.2022.1060721. PMID: 36531454; PMCID: PMC9751055. 2: Huang Y, Wang C, Wang M, Xiong T, Song X, Sun W, Li J. Oroxin B improves metabolic-associated fatty liver disease by alleviating gut microbiota dysbiosis in a high-fat diet-induced rat model. Eur J Pharmacol. 2023 Jul 15;951:175788. doi: 10.1016/j.ejphar.2023.175788. Epub 2023 May 12. PMID: 37179040. 3: Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ. Oroxin B Attenuates Ovariectomy- Induced Bone Loss by Suppressing Osteoclast Formation and Activity. Drug Des Devel Ther. 2021 Nov 30;15:4811-4825. doi: 10.2147/DDDT.S328238. PMID: 34876805; PMCID: PMC8643139. 4: Feng R, Zhang X, Yin J, Zhang Y, Ma Y, Zhang X, Zhang L, Li D. A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. J Pharm Biomed Anal. 2021 Apr 15;197:113905. doi: 10.1016/j.jpba.2021.113905. Epub 2021 Jan 18. PMID: 33636644. 5: Niu K, Yan H, Guo C, Zhang S, Zhu W, Teng S. Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC-MS/MS assay. Biomed Chromatogr. 2019 Mar;33(3):e4417. doi: 10.1002/bmc.4417. Epub 2018 Nov 22. PMID: 30367489. 6: Yang N, Sun H, Xi L, Zhang L, Lu Y, Wang Q, Cao J, Song J, Tang B, Shang L, Zhou X. Oroxin B Resembles Bisoprolol in Attenuating Beta1-Adrenergic Receptor Autoantibody-Induced Atrial Remodelling via the PTEN/AKT/mTOR Signalling Pathway. Clin Exp Pharmacol Physiol. 2025 Feb;52(2):e70011. doi: 10.1111/1440-1681.70011. PMID: 39648364. 7: Li N, Men W, Zheng Y, Wang H, Meng X. Oroxin B Induces Apoptosis by Down- Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer. Molecules. 2019 Nov 30;24(23):4384. doi: 10.3390/molecules24234384. PMID: 31801250; PMCID: PMC6930563. 8: Yang P, Fu S, Cao Z, Liao H, Huo Z, Pan Y, Zhang G, Gao A, Zhou Q. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor- adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79. doi: 10.1016/j.taap.2015.07.026. Epub 2015 Aug 4. PMID: 26253462. 9: Li NN, Meng XS, Bao YR, Wang S, Li TJ. Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer. Pharmacogn Mag. 2018 Apr-Jun;14(54):207-213. doi: 10.4103/pm.pm_119_17. Epub 2018 Apr 10. PMID: 29720833; PMCID: PMC5909317. 10: CHENG CL, CHAO TY. [CHEMICAL STUDIES ON OROXYLEUM INDICUM (L.) VENT. I. TWO NEW FLAVONE GLUCOSIDES OROXIN A AND OROXIN B]. Yao Xue Xue Bao. 1964 Nov;11:762-7. Chinese. PMID: 14235244.