MedKoo Cat#: 128296 | Name: Ampkinone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.

Chemical Structure

Ampkinone
Ampkinone
CAS#1233082-79-5

Theoretical Analysis

MedKoo Cat#: 128296

Name: Ampkinone

CAS#: 1233082-79-5

Chemical Formula: C31H23NO6

Exact Mass: 505.1525

Molecular Weight: 505.53

Elemental Analysis: C, 73.65; H, 4.59; N, 2.77; O, 18.99

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Ampkinone
IUPAC/Chemical Name
2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethylchromeno[3,4-e]isoindole-1,3(2H,4H)-dione
InChi Key
BRRCHDIWBKOMEC-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H23NO6/c1-31(2)25-20(21-15-16-23(37-3)27(34)28(21)38-31)13-14-22-24(25)30(36)32(29(22)35)19-11-9-18(10-12-19)26(33)17-7-5-4-6-8-17/h4-16,34H,1-3H3
SMILES Code
O=C1N(C2=CC=C(C(C3=CC=CC=C3)=O)C=C2)C(C4=C1C=CC5=C4C(C)(C)OC6=C(O)C(OC)=CC=C65)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 505.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oh S, Kim SJ, Hwang JH, Lee HY, Ryu MJ, Park J, Kim SJ, Jo YS, Kim YK, Lee CH, Kweon KR, Shong M, Park SB. Antidiabetic and antiobesity effects of Ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase. J Med Chem. 2010 Oct 28;53(20):7405-13. doi: 10.1021/jm100565d. PMID: 20873794. 2: Zhang J, Kong X, Wang Z, Gao X, Ge Z, Gu Y, Ye P, Chao Y, Zhu L, Li X, Chen S. AMP-activated protein kinase regulates glycocalyx impairment and macrophage recruitment in response to low shear stress. FASEB J. 2019 Jun;33(6):7202-7212. doi: 10.1096/fj.201801869RRR. Epub 2019 Mar 12. PMID: 30860864. 3: Li X, Xu H, Li C, Qiao G, Farooqi AA, Gedanken A, Liu X, Lin X. Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway. Front Pharmacol. 2019 Apr 2;10:319. doi: 10.3389/fphar.2019.00319. PMID: 31001120; PMCID: PMC6454023.