MDI-114215 is a novel, potent allosteric dual-LIMK1/2inhibitor that demonstrates exquisite kinome selectivity. MDI-114215 reduces phospho-cofilin in mouse brain slices and rescues impaired hippocampal long-term potentiation in brain slices from FXS mice. We also show that LIMK inhibitors are effective in reducing phospho-cofilin levels in iPSC neurons derived from FXS patients, demonstrating 85 to be a potential therapeutic candidate for FXS that could have broad application to neurological disorders or cancers caused by LIMK1/2 overactivation and actin instability.
MedKoo Cat#: 128286
Name: MDI-114215
CAS#: N/A
Chemical Formula: C26H29N3O4S
Exact Mass: 479.1879
Molecular Weight: 479.60
Elemental Analysis: C, 65.11; H, 6.10; N, 8.76; O, 13.34; S, 6.68
The following data is based on the product molecular weight 479.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
