DOTA-NI-FAPI-04 | ligand | FAPI Radiotracers

MedKoo Cat#: 128284 | Name: DOTA-NI-FAPI-04

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DOTA-NI-FAPI-04 is a ligand for making [68Ga]Ga/[177Lu]Lu-DOTA-NI-FAPI-04, which is a new FAPI Radiotracers with Improved Tumor Uptake and Retention.

Chemical Structure

DOTA-NI-FAPI-04

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128284

Name: DOTA-NI-FAPI-04

CAS#: N/A

Chemical Formula: C51H69F2N15O14

Exact Mass: 1153.5116

Molecular Weight: 1154.20

Elemental Analysis: C, 53.07; H, 6.03; F, 3.29; N, 18.20; O, 19.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DOTA-NI-FAPI-04; DOTA-NI FAPI-04; DOTA NI-FAPI-04; DOTA-NI-FAPI 04

IUPAC/Chemical Name

2,2',2''-(10-(2-(((S)-1-(4-(3-((4-((2-((S)-2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-5-((3-(2-nitro-1H-imidazol-1-yl)propyl)amino)-1,5-dioxopentan-2-yl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

InChi Key

NOHPIPXXXSPYDL-UNNQYVMBSA-N

InChi Code

InChI=1S/C51H69F2N15O14/c52-51(53)28-36(29-54)67(35-51)44(71)30-58-48(78)38-7-9-55-40-4-3-37(27-39(38)40)82-26-2-11-60-22-24-65(25-23-60)49(79)41(5-6-42(69)56-8-1-12-66-13-10-57-50(66)68(80)81)59-43(70)31-61-14-16-62(32-45(72)73)18-20-64(34-47(76)77)21-19-63(17-15-61)33-46(74)75/h3-4,7,9-10,13,27,36,41H,1-2,5-6,8,11-12,14-26,28,30-35H2,(H,56,69)(H,58,78)(H,59,70)(H,72,73)(H,74,75)(H,76,77)/t36?,41-/m0/s1

SMILES Code

FC1(F)CN(C(CNC(C2=CC=NC3=CC=C(OCCCN4CCN(C([C@@H](NC(CN5CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC5)=O)CCC(NCCCN6C=CN=C6[N+]([O-])=O)=O)=O)CC4)C=C23)=O)=O)[C@H](C#N)C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,154.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Luo Y, Jin W, Zang J, Wang G, Zhu L, Kung HF. Development of [68Ga]Ga/[177Lu]Lu-DOTA-NI-FAPI-04 Containing a Nitroimidazole Moiety as New FAPI Radiotracers with Improved Tumor Uptake and Retention. J Med Chem. 2024 Dec 22. doi: 10.1021/acs.jmedchem.4c02015. Epub ahead of print. PMID: 39710979.