Synonym
Anticancer agent 73; CIB3b; CIB-3b
IUPAC/Chemical Name
ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
InChi Key
DAFRLXQGMZPMLA-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15NO4/c1-4-18-14(16)12-9(2)19-13(15-12)10-5-7-11(17-3)8-6-10/h5-8H,4H2,1-3H3
SMILES Code
O=C(C1=C(C)OC(C2=CC=C(OC)C=C2)=N1)OCC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
261.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Peng T, He Y, Wang T, Yu J, Ma X, Zhou Z, Sheng Y, Li L, Peng H, Li S, Zou J,
Yuan Y, Zhao Y, Shi H, Li F, Liu W, Hu K, Lu X, Zhang G, Wang F. Discovery of a
Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against
Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem.
2022 Aug 25;65(16):11010-11033. doi: 10.1021/acs.jmedchem.2c00189. Epub 2022 Jun
13. PMID: 35695407.
2: Shi H, Yu J, Li L, Ji M, Li R, Peng T, Cheng Y, Wang T, Yang L, Wu Z, Zhang
G, Wang F, Lu X. Design, Synthesis, and Antitumor Activity Evaluation of
2-Phenylthiazole-5-Carboxylic Acid Derivatives Targeting Transactivation
Response RNA-Binding Protein 2. J Med Chem. 2024 Dec 26. doi:
10.1021/acs.jmedchem.4c02041. Epub ahead of print. PMID: 39722648.