MedKoo Cat#: 128277 | Name: JTT-553

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JTT-553 is a DGAT1 inhibitor with IC 50 = 2.38 nM.

Chemical Structure

JTT-553
JTT-553
CAS#701232-94-2

Theoretical Analysis

MedKoo Cat#: 128277

Name: JTT-553

CAS#: 701232-94-2

Chemical Formula: C25H27F3N4O3

Exact Mass: 488.2035

Molecular Weight: 488.51

Elemental Analysis: C, 61.47; H, 5.57; F, 11.67; N, 11.47; O, 9.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JTT-553; JTT 553; JTT553
IUPAC/Chemical Name
2-[6-[4-amino-7,7-dimethyl-2-(trifluoromethyl)pyrimido[4,5-b][1,4]oxazin-6-yl]spiro[1,2-dihydroindene-3,4'-cyclohexane]-1'-yl]acetic acid
InChi Key
YFJNLPDVCDNOMJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)
SMILES Code
O=C(O)CC1CCC2(CC1)CCC3=C2C=CC(C4=NC5=C(N)N=C(C(F)(F)F)N=C5OC4(C)C)=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 488.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tomimoto D, Okuma C, Ishii Y, Kobayashi A, Ohta T, Kakutani M, Imanaka T, Ogawa N. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice. J Pharmacol Sci. 2015 Sep;129(1):51-8. doi: 10.1016/j.jphs.2015.08.005. Epub 2015 Aug 29. PMID: 26354408. 2: Tomimoto D, Okuma C, Ishii Y, Akiyama Y, Ohta T, Kakutani M, Ohkuma Y, Ogawa N. Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluo romethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1' -inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol transferase (DGAT) 1 inhibitor. Biol Pharm Bull. 2015;38(2):263-9. doi: 10.1248/bpb.b14-00655. PMID: 25747985. 3: Yokoyama H, Kobayashi A, Kondo K, Oshida SI, Takahashi T, Masuyama T, Shoda T, Sugai S. A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor. J Toxicol Sci. 2018;43(2):135-157. doi: 10.2131/jts.43.135. PMID: 29479035.