Synonym
JTT-553; JTT 553; JTT553
IUPAC/Chemical Name
2-[6-[4-amino-7,7-dimethyl-2-(trifluoromethyl)pyrimido[4,5-b][1,4]oxazin-6-yl]spiro[1,2-dihydroindene-3,4'-cyclohexane]-1'-yl]acetic acid
InChi Key
YFJNLPDVCDNOMJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)
SMILES Code
O=C(O)CC1CCC2(CC1)CCC3=C2C=CC(C4=NC5=C(N)N=C(C(F)(F)F)N=C5OC4(C)C)=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
488.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tomimoto D, Okuma C, Ishii Y, Kobayashi A, Ohta T, Kakutani M, Imanaka T,
Ogawa N. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1
inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM
mice. J Pharmacol Sci. 2015 Sep;129(1):51-8. doi: 10.1016/j.jphs.2015.08.005.
Epub 2015 Aug 29. PMID: 26354408.
2: Tomimoto D, Okuma C, Ishii Y, Akiyama Y, Ohta T, Kakutani M, Ohkuma Y, Ogawa
N. Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluo
romethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'
-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl
CoA:diacylglycerol transferase (DGAT) 1 inhibitor. Biol Pharm Bull.
2015;38(2):263-9. doi: 10.1248/bpb.b14-00655. PMID: 25747985.
3: Yokoyama H, Kobayashi A, Kondo K, Oshida SI, Takahashi T, Masuyama T, Shoda
T, Sugai S. A pharmacologic increase in activity of plasma transaminase derived
from small intestine in animals receiving an acyl CoA: diacylglycerol
transferase (DGAT) 1 inhibitor. J Toxicol Sci. 2018;43(2):135-157. doi:
10.2131/jts.43.135. PMID: 29479035.