SLU-10906 is a a Potent Inhibitor of Cryptosporidium. SLU-10906 is 10-fold more potent than SLU-2815 against the parasite in a cell-based infection model (EC50 = 0.19 μM) and non-cytotoxic. SLU-10906 has a fast rate of parasite-killing and is orally efficacious in a Cryptosporidium mouse infection model (50 mg/kg BID), although relapse was observed 7 days post-drug treatment. The partial selectivity profile versus human phosphodiesterases is preserved with the benzoxaborole motif and represents an important feature to improve in future optimization.
MedKoo Cat#: 128269
Name: SLU-10906
CAS#: N/A
Chemical Formula: C22H21BFN5O2
Exact Mass: 417.1772
Molecular Weight: 417.25
Elemental Analysis: C, 63.33; H, 5.07; B, 2.59; F, 4.55; N, 16.78; O, 7.67
The following data is based on the product molecular weight 417.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
