SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 suppresses BRD4 interaction with the p53 tumor suppressor and its biological activity in MDA-MB-231 triple-negative breast cancer (TNBC) cells in vitro and in vivo. SDU-071 suppresses cell proliferation, migration, and invasion by downregulating the expression of BRD4-targeted genes, such as c-Myc and Mucin 5AC, and inducing cell cycle arrest and apoptosis, as demonstrated in cultured MDA-MB-231 TNBC cells. Its antitumor activity is illustrated in an orthotopic mouse xenograft mammary tumor model. SDU-071 is a viable option for potentially treating TNBC as a new BRD4-p53 inhibitor.
MedKoo Cat#: 128268
Name: SDU-071
CAS#: 3036109-10-8
Chemical Formula: C28H25N3O2
Exact Mass: 435.1947
Molecular Weight: 435.53
Elemental Analysis: C, 77.22; H, 5.79; N, 9.65; O, 7.35
The following data is based on the product molecular weight 435.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
