MedKoo Cat#: 128265 | Name: KHK-6
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KHK-6 is an inhibitor for serine/threonine kinase hematopoietic progenitor kinase 1 (HPK 1) with an IC50 of 20 nM.

Chemical Structure

KHK-6
KHK-6
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128265

Name: KHK-6

CAS#: N/A

Chemical Formula: C23H23ClN4O4S

Exact Mass: 486.1129

Molecular Weight: 486.97

Elemental Analysis: C, 56.73; H, 4.76; Cl, 7.28; N, 11.51; O, 13.14; S, 6.58

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
250mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
KHK-6; KHK 6; KHK6
IUPAC/Chemical Name
5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3,3-dimethylisobenzofuran-1(3H)-one
InChi Key
OKVXRIASOQGWNK-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H23ClN4O4S/c1-13(2)33(30,31)19-8-6-5-7-18(19)27-20-17(24)12-25-22(28-20)26-14-9-10-15-16(11-14)23(3,4)32-21(15)29/h5-13H,1-4H3,(H2,25,26,27,28)
SMILES Code
CC(S(=O)(C1=C(C=CC=C1)NC2=C(C=NC(NC3=CC=C4C(OC(C)(C4=C3)C)=O)=N2)Cl)=O)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 486.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Ahn MJ, Kim EH, Choi Y, Chae CH, Kim P, Kim SH. Novel hematopoietic progenitor kinase 1 inhibitor KHK-6 enhances T-cell activation. PLoS One. 2024 Jun 26;19(6):e0305261. doi: 10.1371/journal.pone.0305261. PMID: 38923962; PMCID: PMC11207149.