Coenzyme Q0 (CoQ0) | ubiquinone compound | CAS#605-94-7

MedKoo Cat#: 128244 | Name: Coenzyme Q0

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea.

Chemical Structure

Coenzyme Q0

CAS#605-94-7

Theoretical Analysis

MedKoo Cat#: 128244

Name: Coenzyme Q0

CAS#: 605-94-7

Chemical Formula: C9H10O4

Exact Mass: 182.0579

Molecular Weight: 182.18

Elemental Analysis: C, 59.34; H, 5.53; O, 35.13

Price and Availability

Size	Price	Availability	Quantity
1g	USD 450.00	2 Weeks

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Related CAS #

No Data

Synonym

Coenzyme Q0; CoQ0

IUPAC/Chemical Name

2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione

InChi Key

UIXPTCZPFCVOQF-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3

SMILES Code

O=C1C(OC)=C(OC)C(C(C)=C1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 182.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yang Y, Li J, Yin Y, Guo D, Jin T, Guan N, Shi Y, Xu Y, Liang S, Xia X, Shi C. Antibiofilm activity of coenzyme Q0 against Salmonella Typhimurium and its effect on adhesion-invasion and survival-replication. Appl Microbiol Biotechnol. 2019 Oct;103(20):8545-8557. doi: 10.1007/s00253-019-10095-8. Epub 2019 Aug 29. PMID: 31468089. 2: Chung CH, Yeh SC, Chen CJ, Lee KT. Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells. Evid Based Complement Alternat Med. 2014;2014:246748. doi: 10.1155/2014/246748. Epub 2014 Nov 6. PMID: 25431605; PMCID: PMC4241310. 3: Fan Q, Yan C, Shi C, Xu Y, Ma Y, Zhang C, Peng X, Xia X. Inhibitory Effect of Coenzyme Q0 on the Growth of Staphylococcus aureus. Foodborne Pathog Dis. 2019 May;16(5):317-324. doi: 10.1089/fpd.2018.2559. Epub 2019 Apr 9. PMID: 30964334. 4: Yang HL, Lin MW, Korivi M, Wu JJ, Liao CH, Chang CT, Liao JW, Hseu YC. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859(2):246-61. doi: 10.1016/j.bbagrm.2015.11.001. Epub 2015 Nov 5. PMID: 26548719. 5: Somers-Edgar TJ, Rosengren RJ. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. Anticancer Drugs. 2009 Jan;20(1):33-40. doi: 10.1097/CAD.0b013e328314b5c5. PMID: 18830129. 6: Yang HL, Lin PY, Vadivalagan C, Lin YA, Lin KY, Hseu YC. Coenzyme Q₀ defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells. Arch Toxicol. 2023 Apr;97(4):1047-1068. doi: 10.1007/s00204-023-03456-w. Epub 2023 Feb 27. PMID: 36847822. 7: Contin M, Flor S, Martinefski M, Lucangioli S, Tripodi V. The use of coenzyme Q0 as a template in the development of a molecularly imprinted polymer for the selective recognition of coenzyme Q10. Anal Chim Acta. 2014 Jan 7;807:67-74. doi: 10.1016/j.aca.2013.11.030. Epub 2013 Nov 21. PMID: 24356222. 8: Yang HL, Chang CW, Vadivalagan C, Pandey S, Chen SJ, Lee CC, Hseu JH, Hseu YC. Coenzyme Q₀ inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells. Int J Biol Sci. 2024 May 5;20(8):2790-2813. doi: 10.7150/ijbs.93943. PMID: 38904007; PMCID: PMC11186366. 9: MacDonald MJ, Husain RD, Hoffmann-Benning S, Baker TR. Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0. J Biol Chem. 2004 Jun 25;279(26):27278-85. doi: 10.1074/jbc.M314148200. Epub 2004 Apr 9. PMID: 15075342. 10: Chen H, Tappel AL. Protection of vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to rat blood and tissues in vivo. Free Radic Biol Med. 1995 May;18(5):949-53. doi: 10.1016/0891-5849(94)00238-f. PMID: 7797106.